The University of Tokyo · 농업·생명과학
Tadao Asami 교수의 연구실은 식물 호르몬, 특히 브라시노스테로이드(BR)의 생합성과 기능을 규명하기 위해 합성 화합물의 활용에 초점을 맞추고 있습니다. 브라시노스테로이드 생합성 억제제인 브라시노자졸을 개발하여 식물의 난소형성과 생장 조절 메커니즘을 해부하고 있으며, 이는 식물 생장 조절의 화학생물학적 접근을 대표합니다. 또한, BR 생합성 중간체의 변화를 정량적으로 분석함으로써 약물의 작용 타겟을 규명하는 고도화된 생화학적 분석 기법을 응용하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Screening for brassinosteroid (BR) biosynthesis inhibitors was performed to find chemicals that induce dwarfism in Arabidopsis, mutants that resembled BR biosynthesis mutants that can be rescued by BR. Through this screening experiment, the compound brassinazole was selected as the most potent chemical. In dark-grown Arabidopsis, brassinazole-induced morphological changes were nearly restored to those of wild type by treatment with brassinolide. The structure of brassinazole is similar to pacrob
Brassinazole, a synthetic chemical developed in our laboratory, is a triazole-type brassinosteroid biosynthesis inhibitor that induces dwarfism in various plant species. The target sites of brassinazole were investigated by chemical analyses of endogenous brassinosteroids (BRs) in brassinazole-treated Catharanthus roseus cells. The levels of castasterone and brassinolide in brassinazole-treated plant cells were less than 6% of the levels in untreated cells. In contrast, campestanol and 6-oxocamp
Plant hormones are small molecules that play versatile roles in regulating plant growth, development, and responses to the environment. Classic methodologies, including genetics, analytic chemistry, biochemistry, and molecular biology, have contributed to the progress in plant hormone studies. In addition, chemical regulators of plant hormone functions have been important in such studies. Today, synthetic chemicals, including plant growth regulators, are used to study and manipulate biological s
