Kyoto University · 생화학·유전·분자생물학
타지 아다치 교수의 연구실은 뼈의 기계적 적응과 복합적 생체역학을 다루는 다스케일 생체역학 모델링을 핵심으로 합니다. 특히 뼈의 미세구조적 변화를 고해상도 수치 시뮬레이션을 통해 기계적 자극에 따른 표면 리모델링 과정을 정량적으로 분석하며, osteocyte의 기계적 자극 감지 기전과 세포 간 신호 전달 메커니즘을 통합적으로 모델링합니다. 이와 함께 뼈의 골다골증, 골이질증 등 대사성 질환의 기전을 시뮬레이션할 수 있는 통합형 가상 실험 플랫폼 'V-Bone' 개발에도 주력하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
A computational simulation method for three-dimensional trabecular surface remodeling was proposed, using voxel finite element models of cancellous bone, and was applied to the experimental data. In the simulation, the trabecular microstructure was modeled based on digital images, and its morphological changes due to surface movement at the trabecular level were directly expressed by removing/adding the voxel elements from/to the trabecular surface. A remodeling simulation at the single trabecul
In this study, to investigate mechanical remodeling of cancellous bone from the viewpoint of trabecular surface remodeling due to trabecular level mechanical stimuli, a rate equation for trabecular surface remodeling is proposed based on the uniform stress hypothesis, which suggests that nonuniformity in the local stress distribution on the trabecular surface is the driving force for remodeling. A proposed local rate equation for trabecular surface remodeling is applied to a computational simula
In bone functional adaptation by remodelling, osteocytes in the lacuno-canalicular system are believed to play important roles in the mechanosensory system. Under dynamic loading, bone matrix deformation generates an interstitial fluid flow in the lacuno-canalicular system; this flow induces shear stress on the osteocytic process membrane that is known to stimulate the osteocytes. In this sense, the osteocytes behave as mechanosensors and deliver mechanical information to neighbouring cells thro
Abstract Dense sands, overconsolidated clays and soft rocks exhibit strain‐hardening and strain‐softening behaviour in a certain range of confining pressure. The aim of the present paper is to construct a constitutive model of soft rock that can describe not only the strain‐hardening behaviour, but also the strain‐softening behaviour. An elasto‐plastic constitutive model for soft rock is derived by introducing a stress history tensor The preliminary idea was first reported in the reference, the
Bone structure and function are maintained by well-regulated bone metabolism and remodeling. Although the underlying molecular and cellular mechanisms are now being understood, physiological and pathological states of bone are still difficult to predict due to the complexity of intercellular signaling. We have now developed a novel in silico experimental platform, V-Bone, to integratively explore bone remodeling by linking complex microscopic molecular/cellular interactions to macroscopic tissue
