Hokkaido University · 의학
Takako Chikenji 교수의 연구실은 신경계와 자가면역질환, 특히 류마티스성 관절염, 루푸스 등에서 나타나는 만성 염증 및 섬유화 반응의 분자 기전을 중심으로 연구를 진행하고 있습니다. 주로 TGF-β 및 CTGF와 같은 성장인자와 섬유화, 노화세포, 신경손상이 관절 및 신경조직에 미치는 영향을 분석하며, 이는 만성 관절질환과 신경병변의 새로운 치료 전략 개발에 기여하고자 합니다. 특히, 섬유화, 만성 염증, 노화세포의 조절 메커니즘을 타깃으로 한 생물학적 치료 전략 개발에 초점을 맞추고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Non-inflammatory fibrosis of the subsynovial connective tissue (SSCT) is a hallmark of carpal tunnel syndrome (CTS). The etiology of this finding and its relationship to the development of CTS remain poorly understood. Recent studies have found that transforming growth factor-β (TGF-β) plays a central role in fibrosis. The purpose of this study was to investigate the expression of TGF-β and connective tissue growth factor (CTGF), a downstream mediator of TGF-β, in the pathogenesis of CTS. We com
MSCs may exert their effect by remodelling the chronic inflammatory environment via senescence-related regenerative processes.
Rheumatoid arthritis (RA) is an autoimmune disease caused by inflammation of the synovium and characterized by chronic polyarthritis that destroys bone and cartilage. Fibroblast-like synoviocytes (FLSs) in the synovium of patients with RA can promote cartilage and bone destruction by producing proteins such as matrix metalloproteinases and receptor activator of NF-κB ligand, thereby representing an important therapeutic target for RA. FLSs have several phenotypes depending on which cell surface
Carpal tunnel syndrome (CTS) is an idiopathic disease that results from increased fibrosis of the subsynovial connective tissue (SSCT). A recent study found overexpression of both transforming growth factor-β (TGF-β) and connective tissue growth factor (CTGF) in the SSCT of CTS patients. This study investigated TGF-β and CTGF expression in a rabbit model of CTS, in which SSCT fibrosis is induced by a surgical injury. Levels of TGF-β1 and CTGF at 6, 12, 24 weeks after injury were determined by im
Up to 60% of patients with systemic lupus erythematosus (SLE) experience autonomic symptom. Sympathetic nervous system damage can cause dysfunction of the bone marrow that activates inflammatory cells, potentially causing multiple organ damage. We hypothesized that sympathetic nervous system damage would induce bone marrow dysfunction with multiple organ damage in SLE, and that multiple organ damage could be improved by therapy targeting the nervous system. Here, we showed that damage to autonom
Senescent cells create a microenvironment that directs cytotoxic T cell-mediated responses against normal epidermis in patients with CLE, contributing to disease pathology. Targeting senescent cells and their signaling pathways may offer novel therapeutic strategies for patients with skin lesions from CLE and SLE.
The purpose of this study was to investigate the strengths of four intrinsic muscles of the hand of college baseball players. The strengths of four intrinsic muscle groups were measured by the Rotterdam Intrinsic Hand Myometer (RIHM) which has been developed to assess the abduction of the little finger and index finger, and palmar abduction and opposition of the thumb. The strengths of these four intrinsic muscle groups were compared between baseball players and inexperienced sports players. The
