Kyushu University · 의학
Takanori Honda 교수의 연구실은 주로 만성질환의 예방을 목표로 하며, 특히 운동 부족과 장시간 앉아 있는 생활습관이 대사증후군, 심혈관질환, 당뇨병, 치매 등에 미치는 영향을 체계적으로 연구하고 있습니다. 다양한 측정 방법(가속도계 및 자가 보고)을 활용한 정밀한 신체활동 및 운동 부족 평가 방법 개발에도 주력하고 있으며, 특히 중간 연령층을 중심으로 근육 기능 저하와 비만이 병합된 '다이나페닉 비만'이 심혈관질환 위험을 증가시킬 수 있음을 규명했습니다. 이는 생활습관 개선을 통한 만성질환의 1차 예방 전략 수립에 기여하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Sedentary behavior accumulated in a prolonged manner was associated with an increased risk of metabolic syndrome. In devising public health recommendations for the prevention of metabolic disease, the avoidance of prolonged uninterrupted periods of sedentary behavior should be considered.
Both accelerometer and self-report measurements are similarly associated with cardio-metabolic risk factors in a Japanese working adult population. Subjective and objective measures of sedentary behaviors appear to capture different aspects of behaviors. Further efforts to establish data processing methods integrating objective and subjective measures are needed to more effectively assess sedentary time's relationship to health outcomes.
We constructed a risk prediction model for the development of ASCVD in Japanese adults. This prediction model exhibits great potential as a tool for predicting the risk of ASCVD in clinical practice by enabling the identification of specific risk factors for ASCVD in individual patients.
The findings suggest that higher serum elaidic acid is a possible risk factor for the development of all-cause dementia and AD in later life. Public health policy to reduce industrially produced trans fatty acids may assist in the primary prevention of dementia.
Dynapenic obesity was a significant risk factor for the development of CVD in a general Japanese population. This association was more pronounced among those aged <65 years. Inflammation, and possibly glucose metabolism, might partly mediate this association. Our findings suggest that preventing muscle dysfunction as well as appropriate weight control, especially in middle-age, are important for preventing the development of CVD.
Longer sedentary time was associated with a higher prevalence of diabetes mellitus in a general Japanese population. Insulin resistance appeared to be mainly involved in this association. These results highlight the importance of public health strategies targeting reductions in sedentary time for the primary prevention of diabetes mellitus.
