Kyoto University · 재료과학
노자와 타카시 교수의 연구실은 심장 기능의 기계적 에너지 전환 메커니즘과 세균의 병원성 유전자 획득 메커니즘을 중심으로 한 다학제적 연구를 수행하고 있습니다. 심장에서 심실 수축 에너지의 효율성과 전기적·기계적 특성 간 상관관계를 분석하는 생리학적 연구와, 환자에서 흔한 병원성 세균인 황색포도상구균이 수평 유전자 이동을 통해 독성 특성을 획득하는 메커니즘을 밝히는 분자생물학적 연구가 주요 방향입니다. 특히, 세균의 CRISPR-Cas 시스템과 프로파지 획득 간의 상호작용, 그리고 자가분해 작용을 조절하는 GTPase 단백질의 역할에 초점을 맞추고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
We studied the effects of ventricular end-systolic elastance (Ees) and effective arterial elastance (Ea) on the efficiency of energy transfer from pressure-volume area (PVA) to external mechanical work (EW) in the left ventricle of anesthetized closed-chest dogs. PVA represents the total mechanical energy generated by ventricular contraction, which is an intermediate form of energy between oxygen consumption, the total energy input, and EW, the effective energy output. PVA and EW were determined
Streptococcus pyogenes, one of the major human pathogens, is a unique species since it has acquired diverse strain-specific virulence properties mainly through the acquisition of streptococcal prophages. In addition, S. pyogenes possesses clustered regularly interspaced short palindromic repeats (CRISPR)/Cas systems that can restrict horizontal gene transfer (HGT) including phage insertion. Therefore, it was of interest to examine the relationship between CRISPR and acquisition of prophages in S
The relationship between the total loss under tensile stress and the tilt angle of the [001] out of crystal surface β was studied in 3 percent Si-Fe single crystals. The total loss largely depends upon β. When β is about 2°, the total loss under tensile stress is the smallest, and the decrease of the total loss due to tensile stress is the largest. When β is less than about 2°, the total loss increases as β decreases. In the case of perfect
Autophagy mediates the degradation of cytoplasmic contents in the lysosome and plays a significant role in immunity. Here we identified the small GTPases Rab9A and Rab23 as novel autophagy regulators during Group A streptococcus (GAS) infection. Rab9A was recruited to GAS-containing autophagosome-like vacuoles (GcAVs) after autophagosomal maturation and its activity was required for GcAV enlargement and eventual lysosomal fusion. GcAV enlargement appeared to be related to homotypic fusion of GcA
