Kyoto University · 의학
나카가와 교수의 연구실은 내이의 면역 반응과 청각 손상 복구를 위한 약물 전달 시스템 개발에 초점을 맞추고 있습니다. 특히 생분해성 하이드겔과 PLGA 나노입자를 활용한 국소적 약물 전달 기술을 통해 소음성 청력 손실 및 급성 청력 손실에 효과적인 치료 전략을 모색하고 있으며, IGF-1와 같은 신경보호성 단백질의 지역적 적용이 청력 회복에 기여할 수 있음을 규명하고 있습니다. 이는 청력 손상의 면역학적 기전과 함께 약물 전달의 정밀성과 안전성을 동시에 향상시키는 데 기여하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Immune-mediated inner ear disorder has been well established as a clinical entity; however, the innate immune system of the inner ear is a poorly understood area of research with high clinical and immunological importance. Although the presence of resident tissue macrophages in the inner ear has been suggested, there has been some controversy. In this study, we analyzed the origin of cochlear resident macrophages and the contribution of hematopoietic bone marrow (BM) to the recruitment of macrop
These findings demonstrate that local IGF-1 application through the biodegradable hydrogel has the potential for protection of cochleae from noise trauma.
These findings indicate that PLGA nanoparticles can be an useful drug carrier to the cochlea via local application.
These findings indicate that biodegradable hydrogels can be used for drug delivery to the inner ear.
These findings indicate that local rhIGF-1 treatment via gelatin hydrogels is effective for treatment of NIHL.
Topical IGF1 application using gelatin hydrogels is well tolerated and may be efficacious for hearing recovery in patients with SSHL that is resistant to systemic glucocorticoids.
This study examined the potential of induced pluripotent stem (iPS) cells for use as a source of transplants for the restoration of auditory spiral ganglion neurons. We monitored neurite outgrowth from iPS cell-derived neural progenitors toward cochlear hair cells ex vivo, and followed their survival and fates after transplantation into mouse cochleae in vivo. Neurons derived from iPS cells projected neurites toward cochlear hair cells. The settlement of iPS cell-derived neurons was observed 1 w
UMIN Clinical Trials Registry Number UMIN000004366, October 30th, 2010.
This study aimed to evaluate the potential of embryonic stem cell-derived neural progenitors for use as transplants for the replacement of the auditory primary neurons, spiral ganglion neurons. Mouse embryonic stem cell-derived neural progenitors were implanted into the base of the cochlear modiolus of normal or deafened guinea pigs, which contains spiral ganglion neurons and cochlear nerve fibers. Histological analysis demonstrated the survival and neural differentiation of transplants in the c
The predictable fashion of induction of apoptosis in SG neurons over a well-defined time course in the model in the study will aid studies of the molecular mechanism of cell death and elucidation of a strategy for prevention of SG degeneration.
Lidocaine-loaded PLGA microparticles were shown to be capable of the sustained delivery of lidocaine into the cochlea, suggesting that they could be used for the attenuation of peripheral tinnitus.
SV atrophy appears to be the most prominent anatomic characteristic of aged human cochleae.
