Kyushu University · 의학
Takehiro Torisu 교수의 연구실은 대사질환, 특히 인슐린 저항성과 만성 염증이 연관된 당뇨병의 분자 기전을 중심으로 연구를 진행하고 있습니다. 간과 지방세포에서 SOCS3 단백질의 기능을 유전자 조작을 통해 규명하며, 염증 반응이 대사 균형에 미치는 영향을 분석하고 있습니다. 또한 위암 관련 질환, 특히 헬리코박터 파일로리 음성 MALT 림프종과 위점막 미생물총의 역할에 대해서도 메타게놈 분석을 통해 기전 규명에 힘쓰고 있습니다. 최근에는 소장에서의 내 endoscopy 영상 분석을 위한 AI 기반 객체 인식 기술 개발에도 기여하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Inflammation associates with insulin resistance, which dysregulates nutrient homeostasis and leads to diabetes. The suppressor of cytokine signaling 3 (SOCS3), which is induced by pro-inflammatory cytokines, such as TNFalpha and IL-6, has been implicated in inflammation-mediated insulin resistance in the liver and adipocytes. However, no genetic evidence has been provided for the involvement of SOCS3 on insulin resistance. Here, we generated hepatocyte-specific SOCS3-deficient (L-SOCS3 cKO) mice
These findings indicate that SOCS1 plays important negative roles in fulminant hepatitis and that forced expression of SOCS1 is therapeutic in preventing hepatitis.
There may be an association between atrophic gastritis and atherosclerosis in middle-aged subjects.
Indigo naturalis showed favorable therapeutic efficacy in UC, whereas its therapeutic efficacy in CD appeared to be modest. The risk of severe AEs should be recognized for IN treatment.
To investigate the mucosal microbiota in the stomach of patients with Helicobacter pylori-negative mucosa-associated lymphoid tissue (MALT) lymphoma by means of metagenomic analysis.Although some gastric MALT lymphomas are associated with the presence of H. pylori, other gastric MALT lymphomas occur independently of H. pylori infection. The pathogenesis of H. pylori-negative MALT lymphoma remains unclear.Mucosal biopsy specimens were collected from the gastric body from 33 MALT lymphoma patients
Object detection AI model in small bowel CE using YOLO v5 may provide effective and easy-to-understand reading assistance. In this SEE-AI project, we open our dataset, the weights of the AI model, and a demonstration to experience our AI. We look forward to further improving the AI model in the future.
Because the pathogenesis of gastrointestinal follicular lymphoma (GI-FL) remains unclear, no standardized treatment strategy has been established. Of the gastrointestinal lymphomas, gastric mucosa-associated lymphoid tissue lymphomas are strongly associated with Helicobacter pylori; hence, the microbiota may be involved in GI-FL pathogenesis. However, the association between GI-FL and the microbiota remains uninvestigated. Therefore, we compared the mucosal microbiotas of GI-FL patients with tho
Serum IgA levels appear to be a predictor of mortality, especially cancer mortality in males.
