Kyushu University · 의학
모리 타케시 교수의 연구실은 생고분자와 나노소재의 상호작용을 중심으로 한 생고분자 기반 나노입자 설계 및 그 응용을 연구하고 있습니다. 특히, 온도에 민감한 고분자(PNIPAAm)와 DNA를 결합한 나노입자 시스템을 통해 약물 전달 및 진단 기술의 개발에 기여하고 있습니다. 또한, 진균성 감염의 조기 진단을 위한 바이오마커(1→3)-베타-D-글루칸의 정량 분석 기술과 관련된 임상적 응용 연구도 진행 중입니다. 이와 더불어, 생물학적 기능을 가진 단백질의 구조-기능 관계 규명 및 전구체 가공 메커니즘에 대한 분자생물학적 연구도 수행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The thermal properties and temperature-responsive nanoparticle formation of poly(N-isopropylacrylamide) grafted with single-stranded DNA (PNIPAAm-g-DNA) were investigated. Copolymerization between nonamer single-stranded DNA with a vinyl group at its 5' terminus (DNA macromonomer) and NIPAAm was carried out so that the DNA macromonomer unit content should be less than 1 mol %. The turbidimetry and differential scanning calorimetry of the copolymer showed that the transition temperature increased
The present multicentre clinical study was conducted to assess the clinical utility of a new diagnostic method for deep mycosis in which (1-->3)-beta-D-glucan, a fungal cell wall component existing in plasma, was quantitatively measured by the kinetic turbidimetric Limulus test (WB003). Plasma (1-->3)-beta-D-glucan concentrations were 0.57 +/- 0.10 microgram/l in 92 healthy subjects and 0.62 +/- 0.32 microgram/l in 26 patients with non-mycotic diseases (disease control group). In comparison with
Two types of cDNA for nonspecific lipid transfer protein (nsLTP), identical to sterol carrier protein 2, of rat liver were cloned; one was 787 base pairs (bp) long containing a 429-bp open reading frame of 143 amino acids, with a mass of 15,303 Da (15-kDa protein). The cDNA from the other type was 1966 bp long, including a 1641-bp open reading frame of 547 amino acids, giving a mass of 59,002 Da (60-kDa protein). The deduced primary sequence for the 15-kDa protein was exactly the same as the pub
The first case of human systemic infection by an Aspergillus flavus isolate demonstrated to produce aflatoxins in vitro and in vivo is described. The patient, a 41-year-old man with acute myelogenous leukaemia, developed a complication of suspected pulmonary Aspergillus infection during remission induction therapy. Antifungal chemotherapy brought about a considerable degree of improvement, but remission of the underlying disease was not attained. Bone marrow transplantation was also not effectiv
