Nagoya University · 의학
이 교수의 연구실은 주로 자가면역성 췌장염(AIP)의 정확한 진단과 치료 전략 수립을 위한 내시경 초음파 유도 생검(EUS-FNA/FNB) 기반의 진단 기술 개발에 중점을 두고 있습니다. 특히 22게이지 프랑센 바늘를 활용한 조직 생검의 정밀도 향상과 인공지능 기반의 조직 영상 분석 기술을 접목하여 진단 정확도를 높이는 데 기여하고 있습니다. 또한 췌장 질환에서의 대사 변화, 특히 분지사슬 아미노산(BCAA) 대사와 mTORC1 경로의 상호작용에 대한 기초 연구도 수행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
EUS-FNA is useful in the differentiation of type 1 and type 2 AIP, particularly in seronegative cases.
EUS-FNB with a 22-gauge Franseen needle demonstrated favorable detection rates which would be clinically beneficial for the histological diagnosis of AIP.
Given its guaranteed ability to obtain core specimens and comparable safety, and although the risk of bleeding should be kept in mind, EUS-FNB using a Franseen needle is likely to become a standard procedure for obtaining pancreatic tissue in the near future.
We aimed to develop a new artificial intelligence (AI)-based method for evaluating endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) specimens in pancreatic diseases using deep learning and contrastive learning. We analysed a total of 173 specimens from 96 patients who underwent EUS-FNB with a 22 G Franseen needle for pancreatic diseases. In the initial study, the deep learning method based on stereomicroscopic images of 98 EUS-FNB specimens from 63 patients showed an accuracy of 71.8% f
Branched-chain amino acids (BCAAs) are essential amino acids for mammals and play key roles in the regulation of protein metabolism. However, the effect of BCAA deficiency on protein metabolism in skeletal muscle in vivo remains unclear. Here we generated mice with lower BCAA concentrations by specifically accelerating BCAA catabolism in skeletal muscle and heart (BDK-mKO mice). The mice appeared to be healthy without any obvious defects when fed a protein-rich diet; however, bolus ingestion of
Autoimmune pancreatitis patients show a high prevalence of peripancreatic vascular involvements. Thus, patients with vascular involvements are suitable candidates for steroid therapy with evaluation of its potential merits and demerits, even if they are asymptomatic.
