Kyoto University · 화학
Takuya Kubo 교수의 연구실은 나노입자 기반 약물 전달 시스템과 분자인식 고분자(MIP)를 핵심으로 하여, 약물의 정밀한 방출과 선택적 흡착을 가능하게 하는 스마트 재료 개발에 주력하고 있습니다. 특히 자기성 나노입자와 분자인식 고분자를 조합한 자극 반응성 시스템, 그리고 고분자 기반 광접합제나 C60 기반 고정상 액체크로마토그래피 기술을 통해 의약품 및 생체분자의 고도로 선택적인 분리·정제를 실현하고 있습니다. 이는 암 치료 및 바이오 분석 분야에서의 응용 가능성을 높이고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
A new stimulus-responsive drug delivery system using Fe<sub>3</sub>O<sub>4</sub> nanoparticles coated with molecularly imprinted polymer (MIP) is reported. Magnetic thermal seeds (MTS) with their size controlled between 10 and 20 nm that could generate heat under an alternate current (AC) magnetic field were modified with a thermal-responsive MIP by grafting polymerization for effective release of an anticancer drug, methotrexate (MTX). The MIP-coated MTS showed the superparamagnetic property as
We report molecularly imprinted polymers (MIPs) for selective adsorption of proteins using a poly(ethylene glycol) (PEG)-based cross-linker with ionic monomers. To clarify the utility of the concept for preparation of the imprinted polymers using a PEG-based cross-linker, we employed lysozyme or cytochrome c as a template molecule. A few sulfonic functional monomers including sodium allylsulfonate, 2-acrylamido-2-methylpropanesulfonic acid, and sodium p-styrenesulfonate were utilized. After opti
A highly efficient photocoupling agent, based on perfluorophenylazide (PFPA)-conjugated polyallylamine (PAAm), was developed for the efficient immobilization of polymers, nanoparticles, graphene, and small molecules. The conjugate, PAAm-PFPA, was synthesized, and the percentage of the photoactive moiety, PFPA, can be controlled by the ratio of the two components in the synthesis. By treating epoxy-functionalized wafers with PAAm-PFPA, photoactive surfaces were generated. Compared with the PFPA s
