The University of Osaka · 의학
Tomotaka Sobue 교수의 연구실은 폐암 선별 검사의 정확성과 효율성 향상에 초점을 맞추고 있으며, 특히 저선량 CT를 활용한 폐암 스크리닝의 임상적 유용성과 과진단 위험을 철저히 분석합니다. 흡연과 환경적 요인(예: 조리 연료, 주변인의 흡연)이 비흡연 여성에게 폐암 위험에 미치는 영향을 규명하는 연구도 진행 중입니다. 연구는 주로 대규모 인구 기반 코hort 및 케이스컨트롤 연구를 기반으로 하여 실증적이고 정책적 영향을 가질 수 있는 결과를 도출하고자 합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Screening with low-dose helical CT has potential to improve screening efficacy in terms of reducing lung cancer mortality. An evaluation of efficacy using appropriate methods is urgently required.
In order to update the findings of relative risk associated with cigarette smoking for lung cancer by histologic type in Japan, the data from a population-based cohort study of 91,738 men and women were analyzed. During 1990-1999, 422 lung cancer incident cases were identified. The relative risk for all incident cases associated with current smokers versus non-smokers was 4.5 [95% confidence interval (CI): 3.0-6.8] and 4.2 (95% CI: 2.4-7.2), for men and women, respectively. When divided by histo
To assess the extent of overdiagnosis bias in lung cancer screening, clinical Stage I lung cancer cases detected by chest radiograph examination, with histologic or cytologic evidence of malignancy and not treated by surgical operation, were followed up for more than 10 years. Of 1297 screen-detected and 1297 symptom-detected cases collected from 20 institutions, 42 screen-detected and 27 symptom-detected cases satisfied the study criteria. In about half of the cases, the patients had no contrai
In order to evaluate the efficacy of lung-cancer screening, a case-control study was conducted using the data from 50 areas where population-based lung-cancer screening programmes have been operated by local municipalities. In most areas, chest X-ray examinations for all participants and sputum cytology for high-risk participants were offered annually. Case series consisted of 273 deceased lung-cancer cases. For each case, 2 to 5 controls (a total of 1,269 controls) were collected from those who
A hospital-based case-control study among non-smoking women was conducted to clarify risk factors in non-smoking females in Japan. Cases consisted of 144 non-smoking female lung cancer patients, and these were compared to 713 non-smoking female controls. The odds ratio (95% confidence interval) for use of wood or straw as cooking fuels when subjects were 30 years old was estimated as 1.77 (1.08 to 2.91). For those whose household members, other than husbands, had smoked, the odds ratio was estim
