The University of Osaka · 의학
토모야 히로세 교수의 연구실은 심각한 질환 환자에서의 면역 반응 및 조직 손상 메커니즘을 중심으로 한 임상기반의 응급의학 및 신경외과학 연구를 수행하고 있습니다. 특히 중환자에서의 네티큘레이션(넷워크 형성)과 히스톤 H3의 시트룰리네이션, 뇌부종의 분자 메커니즘 등 신체의 염증 반응과 조직 손상 간의 연관성을 규명하고자 합니다. 또한 심 cardiopulmonary resuscitation(CPR)의 질적 향상과 응급 상황 대처 능력 향상을 위한 교육 프로그램 개발에도 기여하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Neutrophil extracellular traps (NETs), a newly identified immune mechanism, are induced by inflammatory stimuli. Modification by citrullination of histone H3 is thought to be involved in the in vitro formation of NETs. The purposes of this study were to evaluate whether NETs and citrullinated histone H3 (Cit-H3) are present in the bloodstream of critically ill patients and to identify correlations with clinical and biological parameters. Blood samples were collected from intubated patients at th
The impact of time of day or day of week on the survival of emergency trauma patients is still controversial. The purpose of this study was to evaluate the outcomes of these patients according to time of day or day of week of emergency admission by using data from the nationwide Japan Trauma Data Bank (JTDB).This study enrolled 236,698 patients registered in the JTDB database from 2004 to 2015, and defined daytime as 09:00 AM to 16:59 PM and nighttime as 17:00 PM to 08:59 AM, weekdays as Monday
The serial changes in the cerebral rSO<sub>2</sub> values during ECPR may predict a patient's neurological outcome. The further evaluation of the validity of rSO<sub>2</sub> monitoring during ECPR may lead to a new resuscitation strategy.
A 45-min simplified CPR training program on chest compression and AED use improved CPR quality and the attitude towards CPR and AED use of non-medical staff of a university hospital.
Handlebar injuries in children have significant potential to cause severe damage to visceral organs, especially those in the abdomen.
The mechanisms accounting for the development of tissue damage following traumatic brain injury (TBI) have been studied for several decades. A variety of mediators, such as vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9), which play a crucial role in edema formation after TBI, have been identified. We experienced a case of brain edema that progressed continuously at least until 13 days after head injury. The brain edema occurred around the hemorrhage from an intr
We could measure serial changes in cerebral rSO2 in seven patients with OHCA in the pre-hospital setting. Our data suggest that pre-hospital monitoring of cerebral rSO2 might lead to a new resuscitation strategy.
Hereditary angioedema (HAE) with deficiency of C1 inhibitor (C1-INH) is an autosomal-dominant disease characterized by recurrent episodes of potentially life-threatening angioedema. The objective is to study the incidence of HAE among patients who visit the emergency department.This was a 3-year prospective observational screening study involving 13 urban tertiary emergency centers in Osaka prefecture, Japan. Patients were included if they met the following criteria: unexplained edema of the bod
