Kyushu University · 의학
Takenaka 교수의 연구실은 비소세포성 폐암의 치료 반응성과 생물학적 특성에 초점을 맞춘 임상 기반의 종양학 연구를 수행하고 있습니다. DNA 복구 효소의 발현과 화학요법 민감도, EGFR 돌연변이 상태, PET-CT에서의 대사 활성 지표(SUVmax)와 종양 생물학적 특성의 연관성 등 다양한 생물학적 마커를 통해 개인화된 치료 전략을 모색하고 있습니다. 특히 재발성 폐암의 임상적 특성과 치료 반응의 관계를 분석함으로써, 보다 정밀한 진단 및 치료 접근법을 개발하고자 합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
DNA repair enzyme expression in tumor cells possibly affects sensitivity to anti-cancer agents. The aim of this study was to determine the relationship between expression status of DNA repair enzymes and chemosensitivity in patients with non-small cell lung cancer (NSCLC). NSCLC tissues prepared from the surgical specimens of 41 patients were subjected to immunohistochemical analysis for Rad51 and ERCC1 proteins and to a chemosensitivity test using the MTT assay. The relationships between the ex
It is essential for recurrent NSCLC patients to be examined for the EGFR mutation status. Patients with a positive EGFR mutation status receive significant benefits from EGFR-TKI therapy.
The PRS of patients with recurrent NSCLC was different depending on the patient's background characteristics and initial treatment for recurrence.
The SUV(max) was associated with the expression of Ki-67 and VEGF in NSCLC. These findings indicated that the SUV(max) of primary tumors might therefore reflect the biological malignant potential in NSCLC.
Short-term smoking cessation intervention did not enough reduce the PPCs as much as in former or never smokers.
Thymoma is an epithelial neoplasm of the thymus, which commonly lies in the anterior mediastinum and, therefore, an intrathoracic origin is considered to be rare. This report presents a case of giant thymoma arising in the thoracic cavity. A 61-year-old male presented with a chronic cough and breathlessness. Chest CT revealed a well enhanced giant mass approximately 18 cm in diameter in the right thoracic cavity. FDG-PET showed that the SUVmax of the tumor was 5.0 in the center and almost 2.5 in
The PNI might help clinicians appropriately identifying patients with better treatment outcomes when receiving first-line ICI therapy.
The distance between home and the hospital was not found to influence the long-term outcomes of the patients with surgically resected NSCLC. Therefore, the travel distance should not represent a contraindication to surgical resection and postoperative therapy for NSCLC.
