Kyushu University · 의학
오오라 토모유키 교수의 연구실은 일본 노인층을 대상으로 한 장기적 관찰 연구를 바탕으로 인지기능 저하 및 치매의 주요 위험 요인을 규명하고 있습니다. 당뇨병, 수면 패턴, 흡연, 치아 건강, 식이요법 등 생활습관과 신체적 요인의 영향을 중심으로 연구를 진행하며, 특히 2시간 후 포도당 수치와 우유·유제품 섭취가 치매 발생에 미치는 영향에 초점을 맞추고 있습니다. 이는 예방 중심의 뇌건강 전략 수립에 기여할 임상적 통찰을 제공합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Our findings suggest that diabetes is a significant risk factor for all-cause dementia, AD, and probably VaD. Moreover, 2-hour PG levels, but not FPG levels, are closely associated with increased risk of all-cause dementia, AD, and VaD.
The increased incidence and improved survival rate of AD could have resulted in the steep increase in AD prevalence in the Japanese elderly.
Tooth loss is associated with an increased risk of all-cause dementia and AD in the Japanese population.
Greater milk and dairy intake reduced the risk of dementia, especially AD, in the general Japanese population.
Short and long daily sleep duration and hypnotic use are risk factors for dementia and death in Japanese elderly adults.
Persistent smoking from mid- to late life is a significant risk factor for dementia and its subtypes in the general Japanese population.
The present findings suggest a significant association between increased serum sTREM2 levels and the risk of developing all-cause dementia, AD, and VaD in the general elderly Japanese population. ANN NEUROL 2019;85:47-58.
Our findings suggest that the total number of regions with grey matter atrophy among the medial temporal lobe, insula, hippocampus and amygdala is a significant predictor for developing dementia, especially AD, in the general older population.
APOE is an established susceptibility gene for late-onset Alzheimer's disease (LOAD). Recent genome-wide association studies have identified many additional susceptibility genes for LOAD in populations of European descent. However, there is little information on whether or not genetic variants in these genes are associated with other ethnicities. To investigate the association of seven genes identified by genome-wide association studies, we carried out a case-control study using 825 LOAD cases a
The APOE-ɛ4 allele is a risk factor for AD in the Japanese population. Information on APOE genotype improves AD risk assessment substantially beyond a model based on potential risk factors.
Objective: We investigated the association between glucose tolerance status defined by a 75-g oral glucose tolerance test (OGTT) and the development of dementia. Methods: A total of 1,017 community-dwelling dementia-free subjects aged 60 years who underwent the OGTT were followed up for 15 years. Outcome measure was clinically diagnosed dementia. Results: The age- and sex-adjusted incidence of all-cause dementia, Alzheimer disease (AD), and vascular dementia (VaD) were significantly higher in su
The association between diabetes mellitus and the risk of developing dementia has received much attention in epidemiological studies. However, the results from these studies are still inconclusive. An accurate population-based prospective cohort study of dementia was begun in 1985 in the town of Hisayama, Japan. To examine the association between the glucose tolerance status and development of dementia, a total of 1,017 community-dwelling dementia-free subjects aged > or = 60 years who underwent
Background Epidemiological evidence implies a link between heart disease and dementia. However, few prospective studies have assessed the association between serum NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels and dementia. Methods and Results A total of 1635 community-dwelling Japanese elderly aged ≥60 years without dementia (57% women, mean age±SD 70.8±7.7 years) were followed up for 10 years. Serum NT-proBNP levels were divided into 4 categories (≤54, 55-124, 125-299, and ≥300
