Hokkaido University · 의학
이 교수의 연구실은 척추 연골의 비정상적 석회화인 후방인대화증(OPLL)과 연막화증(OLF)의 발병 메커니즘과 대사 이상 간의 연관성을 중심으로 연구를 진행하고 있습니다. 특히 비만, 이상지질혈증, 비알코올성간지방증(NAFLD)과 같은 대사증후군 요법이 OPLL/OLF의 진행에 미치는 영향을 임상적·영상학적 데이터를 기반으로 규명하고 있습니다. 또한 어류의 난세포에서의 지질 흡수 조절 메커니즘을 연구함으로써 대사 조절의 기초 메커니즘을 탐색하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
To investigate the regulation of lipid uptake into the eel oocyte in more detail, effects of 11-ketotestosterone (11-KT) and lipid transporters (lipoproteins) were determined in vitro. Ovarian explants from previtellogenic Japanese eels (Anguilla japonica) were incubated for 28 days with 11-KT and/or with very low density lipoproteins (Vldl), low density lipoproteins (Ldl), or high density lipoproteins (Hdl) purified from eel plasma. The androgen 11-KT induced notable increases in oocyte diamete
Vitamin A deficiency resulting from unbalanced dietary habits is associated with exacerbation of male early-onset OPLL.
Our findings demonstrated that obesity is a distinct feature of multilevel OLF in the thoracic spine and that the severity of OLF is associated with the degree of obesity.
Obesity and metabolic disturbances are prevalent in ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum (OLF); however, the involvement of dyslipidemia (DL) in OPLL/OLF remains uncertain. We investigated the association between dyslipidemia and OPLL/OLF using a dataset of 458 individuals receiving health screening tests, including computed tomography. Subjects were grouped according to the presence or location of OPLL/OLF: controls (no OPLL/OLF, n
Ossification of the posterior longitudinal ligament (OPLL) of the spine is a disease of unknown etiology occurring frequently in individuals with metabolic disturbances. Obesity has been suggested as a potential risk factor for the severity of OPLL. We aimed to investigate whether non-alcoholic fatty liver disease (NAFLD) is associated with OPLL severity. We assessed the severity of NAFLD by a liver-to-spleen (L/S) ratio on computed tomography (CT) scans of 85 symptomatic OPLL patients at a sing
Pioglitazone could not reduce the occurrence of cardiovascular events in patients with mild DM and previous MI.
One of the approaches to reducing the size of half-wavelength linear dipole antennas is the meander dipole antenna, where the elements form a meander line. This paper presents a formula for the relationship between the geometrical size and the resonant frequency of the meander line dipole antenna, and a calculation formula for the radiative efficiency is derived from the result. It is shown that the geometrical parameters of the meander line dipole antenna can be determined from the specified ra
