성균관대학교 · Biochemistry, Genetics and Molecular Biology
Wonhwa Lee 교수의 연구실은 염증 반응과 혈관 기능 장애를 중심으로 한 질병 메커니즘을 규명하고, 이를 해결하기 위한 신약 후보 물질 개발에 주력하고 있습니다. 특히 코로나19와 세프시스 등 급성 염증성 질환에서의 스테로이드 조절 단백질(SREBP-2), 엔도칸, 마스린산, 올레아노릭 산 등 자연물 유래 화합물의 면역조절 및 항응고 작용 메커니즘을 연구하고 있습니다. 또한 혈관 투과성 유지, 림프구 이행 억제, 데드 세포 제거 기능 등 혈관 내피 기능 회복을 위한 신호전달 경로를 탐색하고 있습니다. 이는 염증성 질환 치료제 개발에 기여할 임상적 전망을 지닌 연구입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Sterol regulatory element binding protein-2 (SREBP-2) is activated by cytokines or pathogen, such as virus or bacteria, but its association with diminished cholesterol levels in COVID-19 patients is unknown. Here, we evaluated SREBP-2 activation in peripheral blood mononuclear cells of COVID-19 patients and verified the function of SREBP-2 in COVID-19. Intriguingly, we report the first observation of SREBP-2 C-terminal fragment in COVID-19 patients' blood and propose SREBP-2 C-terminal fragment
Endocan is a proteoglycan secreted by endothelial cells under the control of inflammatory cytokines. The aim of this study was to evaluate the effects of endocan on proinflammatory responses and on septic mice and underlying mechanisms. Human umbilical vein endothelial cells (HUVECs) or mice were exposed to lipopolysaccharide (LPS) or endocan with or without neutralizing endocan antibody. Mice were subjected to cecal ligation and puncture (CLP) surgery with or without neutralizing endocan antibo
Maslinic acid (MA), a natural compound of the triterpenoid group derived from olive, prevents the generation of pro-inflammatory cytokines and oxidative stress. In human umbilical vein endothelial cells (HUVECs) treated with lipopolysaccharide (LPS), we characterized the effects of MA on the regulation of heme oxygenase (HO)-1, cyclooxygenase (COX-)2, and inducible nitric oxide synthase (iNOS). MA was tested in the lung tissues of LPS-treated mice, to determine its effect on levels of iNOS expre
