성균관대학교 · 생화학·유전·분자생물학
양운석 교수의 연구실은 식품 기능성과 생리적 기능을 연계한 자연소재 기반의 기능성 식품 개발을 핵심으로 합니다. 특히 콩, 오ats, 청국장과 같은 전통 발효식품에서 유래한 생리활성 물질(소포티드, β-글루칸, 아르티아미드 등)의 기능성 메커니즘과 질병 예방 효과를 연구하고 있으며, 면역 조절, 혈관 건강, 대사질환 예방 등에 기여하는 천연물질의 기전 규명을 목표로 합니다. 또한, MMP 억제제 등 천연물 기반의 신약 후보 물질 개발에 대한 연구도 진행 중입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
In addition to providing nutrients, food can help prevent and treat certain diseases. In particular, research on soy products has increased dramatically following their emergence as functional foods capable of improving blood circulation and intestinal regulation. In addition to their nutritional value, soybeans contain specific phytochemical substances that promote health and are a source of dietary fiber, phospholipids, isoflavones (e.g., genistein and daidzein), phenolic acids, saponins, and
Peptides present in foods are involved in nutritional functions by supplying amino acids; sensory functions related to taste or solubility, emulsification, etc.; and bioregulatory functions in various physiological activities. In particular, peptides have a wide range of physiological functions, including as anticancer agents and in lowering blood pressure and serum cholesterol levels, enhancing immunity, and promoting calcium absorption. Soy protein can be partially hydrolyzed enzymatically to
Oats (<i>Avena sativa</i> L.) are rich in protein, fiber, calcium, vitamins (B, C, E, and K), amino acids, and antioxidants (beta-carotene, polyphenols, chlorophyll, and flavonoids). β-glucan and avenanthramides improve the immune system, eliminate harmful substances from the body, reduce blood cholesterol, and help with dietary weight loss by enhancing the lipid profile and breaking down fat in the body. β-glucan regulates insulin secretion, preventing diabetes. Progladins also lower cholestero
Cheonggukjang (CGJ, fermented soybean paste), a traditional Korean fermented dish, has recently emerged as a functional food that improves blood circulation and intestinal regulation. Considering that excessive consumption of refined salt is associated with increased incidence of gastric cancer, high blood pressure, and stroke in Koreans, consuming CGJ may be desirable, as it can be made without salt, unlike other pastes. Soybeans in CGJ are fermented by <i>Bacillus</i> strains (<i>B. subtilis</
The antiallergic potential of Arctium lappa L. was investigated in Sprague-Dawley rats, ICR mice, and RBL-2H3 cells. Ethanol extract (90%) of A. lappa (ALE, 100 μg/mL) inhibited the degranulation rate by 52.9%, determined by the level of β-hexosaminidase. ALE suppressed passive cutaneous anaphylaxis (PCA) in rats and attenuated anaphylaxis and histamine release in mice. To identify the active compound of ALE, we subsequently fractionated and determined the level of β-hexosaminidase in all subfra
Considerable research has examined MMP inhibitors, but most of these have been synthetic compounds. Research using natural products as MMP inhibitors has only recently become a subject of interest. This review intends to discuss recent research trends regarding the physiological properties, functions, and therapeutic agents related to MMPs.
The purpose of this study was to investigate antihyperlipidemic and antioxidative potentials of onion (<i>Allium cepa</i> L.) extract fermented with a novel <i>Lactobacillus casei</i> HD-010. In general, fermented onion extract is used for its antioxidative activity (ORAC), inhibitory effect on adipocytes differentiation, quercetin contents, and antihyperlipidemic activities. However, the effect of fermented onion extract on hyperlipidemia after oral administration using ApoE-deficient mice has
Oat (<i>Avena sativa</i> L.) is one of the most widely consumed cereal grains worldwide and is considered as an important cereal crop with high nutritional value and potential health benefits. With different bacterial strains, fermented oat extracts were examined for the antioxidant and antiaging effects on the skin after optimization of extraction conditions. Fermented oats contained high avenanthramides, and its function was investigated on matrix metalloproteinase-1 and collagen expression wi
This study was designed to investigate the potential reproductive health benefits of Raphanus sativus L. (radish) sprout ethanolic extract (RSE) in a bisphenol A (BPA)-exposed rat model of testicular disorders and to identify the bioactive components of RSE. RSE and its butanolic layer (RSE-BuOH) exhibited the strongest total antioxidant capacity, as determined using the oxygen radical absorbance capacity method. The RSE-BuOH was fractionated using chromatography with active guided fractionation
Our results provide evidence that Persicaria nepalensis (Meisn.) Miyabe extract has strong physiological activity without any toxic effects, and furthermore, MPN-1-1 can be potentially utilized as a natural dietary supplement as well as an anti-oxidant.
