연세대학교 · Medicine
Yae Won Park 교수의 연구실은 뇌영상 영상유전학(radiomics)과 기계학습 기반 분석을 핵심으로 하여 뇌신경질환의 정밀의료를 목표로 합니다. 주로 저-grade 뇌신생물질(예: 낮은 등급의 뇌신생물)과 파킨슨병, 정신분열증 등 신경정신질환에서 영상생물학적 지표를 규명하고 있습니다. 특히, MRI 영상에서 추출한 다차원적 영상 특징을 활용해 유전자형질, 치료 반응, 인지기능 저하 등을 예측하는 데 초점을 맞추고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Preoperative MR imaging phenotypes are different according to the molecular markers of lower grade gliomas, and they may be helpful in predicting the <i>IDH1-</i>mutation status.
BG-PVS may be a useful imaging marker for predicting cognitive decline in PD. © 2019 International Parkinson and Movement Disorder Society.
Whole-tumor histogram and texture features of the ADC and fractional anisotropy maps are useful for predicting the <i>IDH1</i>-mutation and 1p/19q-codeletion status in World Health Organization grade II gliomas.
Radiomics feature-based classifiers may be useful to predict LGG grades. However, radiomics classifiers may have a limited value when applied to the nonenhancing LGG subgroup in a TCGA cohort.
The purpose of this study was to establish a high-performing radiomics strategy with machine learning from conventional and diffusion MRI to differentiate recurrent glioblastoma (GBM) from radiation necrosis (RN) after concurrent chemoradiotherapy (CCRT) or radiotherapy. Eighty-six patients with GBM were enrolled in the training set after they underwent CCRT or radiotherapy and presented with new or enlarging contrast enhancement within the radiation field on follow-up MRI. A diagnosis was estab
There is a growing need to develop novel strategies for the diagnosis of schizophrenia using neuroimaging biomarkers. We investigated the robustness of the diagnostic model for schizophrenia using radiomic features from T1-weighted and diffusion tensor images of the corpus callosum (CC). A total of 165 participants [86 schizophrenia and 79 healthy controls (HCs)] were allocated to training (N = 115) and test (N = 50) sets. Radiomic features of the CC subregions were extracted from T1-weighted, a
To investigative whether radiomics features in bilateral hippocampi from MRI can identify temporal lobe epilepsy (TLE). A total of 131 subjects with MRI (66 TLE patients [35 right and 31 left TLE] and 65 healthy controls [HC]) were allocated to training (n = 90) and test (n = 41) sets. Radiomics features (n = 186) from the bilateral hippocampi were extracted from T1-weighted images. After feature selection, machine learning models were trained. The performance of the classifier was validated in
The fifth edition of the World Health Organization (WHO) classification of central nervous system tumors published in 2021 advances the role of molecular diagnostics in the classification of gliomas by emphasizing integrated diagnoses based on histopathology and molecular information and grouping tumors based on genetic alterations. This Part 2 review focuses on the molecular diagnostics and imaging findings of pediatric-type diffuse high-grade gliomas, pediatric-type diffuse low-grade gliomas,