Kyoto University · 의학
타바라 유스카르 교수의 연구실은 당뇨병, 고혈압을 비롯한 대사성 질환의 유전적 기반을 규명하는 데 초점을 맞추고 있습니다. 특히 아프리카계나 일본계 등 특정 인구집단에서 흔한 유전적 소인(G6PD 결핍, T2DM 관련 유전자 변이 등)이 질병 발병에 미치는 영향을 유전체학적 접근을 통해 탐구하고 있습니다. 또한 당화혈색소(HbA1c)의 진단 정확도를 높이기 위한 유전자 기반 보정 기법 개발과 고령층의 근육 및 뼈 건강에 영향을 미치는 AGEs 축적 메커니즘에 대해서도 연구를 진행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
As G6PD deficiency can be clinically silent until illness strikes, we recommend investigation of the possible benefits of screening for the G6PD genotype along with using HbA1c to diagnose T2D in populations of African ancestry or groups where G6PD deficiency is common. Screening with direct glucose measurements, or genetically-informed HbA1c diagnostic thresholds in people with G6PD deficiency, may be required to avoid missed or delayed diagnoses.
Type 2 diabetes susceptibility of seven candidate genes was confirmed in Japanese. Conservation of susceptible loci for type 2 diabetes was independent of ethnic background.
Hypertension is one of the most common complex genetic disorders. We have described previously 38 single nucleotide polymorphisms (SNPs) with suggestive association with hypertension in Japanese individuals. In this study we extend our previous findings by analyzing a large sample of Japanese individuals (n=14 105) for the most associated SNPs. We also conducted replication analyses in Japanese of susceptibility loci for hypertension identified recently from genome-wide association studies of Eu
Abstract Background The accumulation of advanced glycation end product (AGE) might exert deleterious effects on musculoskeletal properties. Our study aims to clarify this possible association in a large general population. Methods This study investigated a general population of 9,203 patients (mean age, 57.8 years). Skeletal muscle mass was measured by bioelectrical impedance analysis, whereas accumulation of AGEs was assessed by skin autofluorescence (SAF-AGE). The muscle strength of upper and
