The University of Tokyo · 의학
오시마 야스시 교수의 연구실은 경추 척추관 협착증(Cervical Spondylotic Myelopathy, CSM)의 임상적 경과와 예후 요인을 중심으로 한 신경외과 및 척추질환 연구를 수행하고 있습니다. 특히, 경과 관찰에서의 신경학적 예후, PRO-JOA 점수를 활용한 질병 특이적 평가 방법 개발, 그리고 연골세포의 괴사 조절 메커니즘(특히 P(i)와 Bnip3/Bcl-xL 신호 경로)에 대한 분자 생물학적 연구를 병행하고 있습니다. 이는 임상적 판단과 기초 생물학적 메커니즘을 연결지어 척추질환의 정밀의료를 추구하는 연구 철학을 반영합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Fifty-six percent of patients with clinically mild CSM with ISI had not deteriorated or undergone surgery at 10 years. Large range of motion, segmental kyphosis, and instability at the narrowest canal were considered to be adverse prognostic factors.
PRO-JOA score can also be used as a disease-specific scoring measure instead of JOA score. However, although both measures demonstrate a similar trend as a group analysis, PRO-JOA and JOA scores should be regarded as different outcomes.
During endochondral ossification, chondrocytes undergo hypertrophic differentiation and die by apoptosis. The level of inorganic phosphate (P(i)) elevates at the site of cartilage mineralization, and when chondrocytes were treated with P(i), they underwent rapid apoptosis. Gene silencing of the proapoptotic Bcl-2 homology 3-only molecule bnip3 significantly suppressed P(i)-induced apoptosis. Conversely, overexpression of Bcl-xL suppressed, and its knockdown promoted, the apoptosis of chondrocyte
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Patients with a low mental state, possibly before surgery, are at a high risk for postoperative axial neck pain. None of the imaging parameters were statistically different.
