Hokkaido University · 의학
이 교수의 연구실은 주로 피부질환, 특히 에피더모리시스 빌로스아(Epidermolysis Bullosa, EB)와 만성 피부염성 피부병변(MF, Mycosis Fungoides) 등의 유전성 및 면역매개 피부질환의 병태생리학을 규명하고, 이를 해결하기 위한 줄기세포 기반 치료 전략을 개발하고 있습니다. 특히 골수유래 면역세포와 Muse 세포를 활용한 유전자 기반 치료 및 조직 재생 치료에 초점을 맞추고 있으며, EB의 구조단백질 결함 회복에 있어 뼈마개 이식(BMT)의 임상적 잠재성을 입증하고 있습니다. 또한, 피부에서의 면역세포 상호작용 및 염증 반응 조절 메커니즘에 대해서도 깊이 있는 연구를 진행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The rate of second-case Kawasaki disease occurring among 1788 siblings of children with the disease was derived from data obtained from questionnaires mailed to the members of the Japanese Association of Parents of Children With Kawasaki Disease. Within 1 year after the onset of the first case in a family, the overall second-case rate was 2.1% for siblings, as compared to an overall incidence of approximately 0.19% in the general population of children 0 to 4 years of age in Japan in the epidemi
URL: https://dbcentre3.jmacct.med.or.jp/jmactr/Default.aspx. Unique identifier: JMA-IIA00022)
Attempts to treat congenital protein deficiencies using bone marrow-derived cells have been reported. These efforts have been based on the concepts of stem cell plasticity. However, it is considered more difficult to restore structural proteins than to restore secretory enzymes. This study aims to clarify whether bone marrow transplantation (BMT) treatment can rescue epidermolysis bullosa (EB) caused by defects in keratinocyte structural proteins. BMT treatment of adult collagen XVII (Col17) kno
Epidermolysis bullosa (EB) is a group of genodermatoses characterized by generalized blisters from mutations in the genes encoding the basement membrane zone (BMZ) proteins.1 The infusion of allogeneic cells such as mesenchymal stem/stromal cells (MSCs), which have intact BMZ genes, is a promising treatment.2-6 We here focus on multilineage-differentiating stress-enduring (Muse) cells, which were initially found as a stem cell marker stage-specific embryonic antigen (SSEA)-3-positive subpopulati
CCR10-CTACK/CCL27 interactions between circulating T cells and keratinocytes would seem to play an important role in the pathophysiology of MF from the early disease stages.
