Yong Bae Kim
연세대학교 의과대학 신경외과학교실 · 의학
이 교수의 연구실은 종양 생물학과 세포 신호전달 메커니즘을 중심으로, 특히 항암 치료 반응 예측 및 암 진행 메커니즘을 규명하는 데 초점을 맞추고 있습니다. COX-2, ILK, PTEN 등 특정 단백질과 신호 경로가 암 세포의 생존, 이동 및 전이에 미치는 영향을 분석하며, 암세포와 면역세포 간의 상호작용, 특히 퇴행세포를 통한 미세환경 조절 메커니즘을 연구하고 있습니다. 또한, 고성능 반도체 소자 제조 공정에서의 산화막 형성 기술에 대한 물리화학적 분석도 함께 수행하고 있어, 의학적 응용과 소재 공학의 융합 연구를 추구합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
COX-2 overexpression can be used as a potent molecular risk factor in patients with FIGO Stage IIB SCC of the uterine cervix who are treated with radiotherapy and concurrent chemotherapy.
ClinicalTrials.gov Identifier: NCT04803266.
Integrin-linked kinase (ILK) is involved in signal transduction by integrin-mediated cell adhesion that leads to dynamic actin reorganization. Actin (de)polymerization is regulated by cofilin, the Ser(3) phosphorylation (pS(3)cofilin) of which inhibits its actin-severing activity. To determine how ILK regulates pS(3)cofilin, we examined the effects of ILK on pS(3)cofilin using normal RIE1 cells. Compared with suspended cells, fibronectin-adherent cells showed enhanced pS(3)cofilin, depending on
Apoptotic cell clearance by phagocytes is essential in tissue homeostasis. We demonstrated that conditioned medium (CM) from macrophages exposed to apoptotic cancer cells inhibits the TGFβ1-induced epithelial-mesenchymal transition (EMT), migration, and invasion of cancer cells. Apoptotic 344SQ (ApoSQ) cell-induced PPARγ activity in macrophages increased the levels of PTEN, which was secreted in exosomes. Exosomal PTEN was taken up by recipient lung cancer cells. ApoSQ-exposed CM from PTEN knock
Formation of ultrathin oxide layer in water‐based processes, resulting in hydroxyl group termination, is an essential process technology for high‐k dielectric stack formation with atomic layer chemical vapor deposition (ALCVD) layers. A silicon(100) surface treated in water vapor in the temperature range of typical ALCVD processes has been studied by high‐resolution X‐ray photoelectron spectroscopy (HRXPS) analysis. cleaned silicon (100) surface is stable in water vapor up to . From , the surfac
We report a case of aggressive 'nasal type' natural killer (NK)/T cell lymphoma initially presenting as a testicular tumor in a Korean man, which quickly took a fatal course by widespread dissemination. Histologically, the testicular mass showed a diffuse dense infiltrate of medium-sized and atypical large lymphoid cells with angiocentric and angiodestructive infiltration and areas of coagulative necrosis on hematoxylin-eosin stained sections. Immunophenotyping by immunohistochemistry yielded su
