Yong‐Hee Kim
한양대학교 생화학과 · 생화학·유전·분자생물학
Yong-Hee Kim 교수의 연구실은 주로 암 치료 및 대사성 질환을 위한 첨단 약물 전달 시스템을 개발하고 있습니다. 특히 나노입자, 마이크로니들, 펩타이드 기반 폴리플렉스를 활용한 정밀한 약물 배달 기술과 유전자 치료를 위한 안정적이고 비침습적인 전달 시스템에 초점을 맞추고 있습니다. 헤모오크시다제-1(HO-1) 조절을 통한 암 저항성 및 대사 증후군 개선 전략도 핵심 연구 주제입니다. 다양한 생체 적합성 소재와 3D 프린팅 기반의 맞춤형 약물 전달 장치 개발도 활발히 진행 중입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Nonarginine (D-R9) has been reported to be one of the most efficacious protein transduction domains (PTDs) for the intracellular cargo delivery such as DNA, RNA, proteins, and particles. Although oligoarginines are capable of forming polyplex with DNA by electrostatic interaction, the length of oligoarginine can affect the toxicity and gene expression. The reducible poly(oligo-D-arginine) (rPOA) composed of the Cys-(D-R9)-Cys repeating unit forming disulfide bonds between terminal cysteinyl-thio
Advancements in micro-resolution 3D printers have significantly facilitated the development of highly complex mass-producible drug delivery platforms. Conventionally, due to the limitations of micro-milling machineries, dissolvable microneedles (MNs) are mainly fabricated in cone-shaped geometry with limited drug delivery accuracy. Herein, to overcome the limitations of conventional MNs, a novel projection micro-stereolithography 3D printer-based self-locking MN for precise skin insertion, adhes
Abstract Nanoparticular drug delivery systems may help to overcome the limitations of conventional chemotherapy. They have been reported to improve the specificity of distribution, the bioavailability, and the solubility of drugs, as well as the duration of drug efficacy, and helping to overcome multidrug resistance. Although various polymeric nanoparticles have been developed for delivery of anticancer agents, most nanoparticles still focus on solubilizing drugs, improving targeting ability, an
