고려대학교 · Neuroscience
이 교수의 연구실은 정신질환의 신경면역학적 기반을 규명하는 데 초점을 맞추고 있으며, 특히 우울증, 조울증, 불안장애 및 정신분열증과 같은 정신질환에서 면역 반응, 염증 반응, 신경전달물질 및 호르몬 조절의 역할을 심층적으로 연구하고 있습니다. 린델리움, 멜라토닌, 사이토카인 균형, 트립토판 대사 등 다양한 생물학적 매개체를 통해 정서 조절과 뇌 기능 이상의 기전을 밝혀내는 데 기여하고 있습니다. 특히 신경염증과 신경생존 신호 경로의 상관관계를 중심으로 치료적 접근의 기반을 마련하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Lithium has been used for the treatment of bipolar disorder (BD) for the last sixty or more years, and recent studies with more reliable designs and updated guidelines have recommended lithium to be the treatment of choice for acute manic, mixed and depressive episodes of BD, along with long-term prophylaxis. Lithium's specific mechanism of action in mood regulation is progressively being clarified, such as the direct inhibition on glycogen synthase kinase 3β, and its various effects on neurotro
Stress-induced changes in the immune system, which lead to neuroinflammation and consequent brain alterations, have been suggested as possible neurobiological substrates of anxiety disorders, with previous literature predominantly focusing on panic disorder, agoraphobia, and generalized anxiety disorder, among the anxiety disorders. Anxiety disorders have frequently been associated with chronic stress, with chronically stressful situations being reported to precipitate the onset of anxiety disor
Cytokine imbalances especially between T helper type (Th) 1 and Th2 and tryptophan breakdown were reported to be involved in the pathophysiology of schizophrenia. The hyperactive inflammatory response system could induce enhanced tryptophan breakdown. This study aimed to investigate the relationship between cytokine changes, tryptophan breakdown parameter changes and clinical parameters in patients with schizophrenia in comparison with normal controls. In the plasma of schizophrenic patients, Th
