허용민 교수

The unique properties of magnetic nanocrystals provide them with high potential as key probes and vectors in the next generation of biomedical applications. Although superparamagnetic iron oxide nanocrystals have been extensively studied as excellent magnetic resonance imaging (MRI) probes for various cell trafficking, gene expression, and cancer diagnosis, further development of in vivo MRI applications has been very limited. Here, we describe in vivo diagnosis of cancer, utilizing a well-defin

Abstract Novel multifunctional magnetic gold nanocomposites (MGNCs) were synthesized for synchronous cancer therapy and diagnosis via magnetic resonance imaging (MRI). The MGNCs consist of magnetic kernels (aggregates of ultra‐sensitive MnFe 2 O 4 magnetic nanocrystals wrapped in polymer) as effective MR contrast agents and silica–gold nanocomposites as hyperthermal therapeutic agents. A therapeutic antibody, Erbitux (ERB), was conjugated for specific tumor cell targeting both to localize the ne

Nanoparticles have been investigated as drug carriers, because they provide a great opportunity due to their advantageous features: (i) various formulations using organic/inorganic materials, (ii) easy modification of targeting molecules, drugs or other molecules on them, (iii) effective delivery to target sites, resulting in high therapeutic efficacy and (iv) controlling drug release by external/internal stimuli. Because of these features, therapeutic efficacy can be improved and unwanted side

Well-designed nanoparticle-mediated, image-guided cancer therapy has attracted interest for increasing the efficacy of cancer treatment. A new class of smart theragnostic nanoprobes employing cetuximab (CET)-conjugated polyethylene glycol (PEG)ylated gold nanorods (CET-PGNRs) is presented; these nanoprobes target epithelial cancer cells using near-infrared light. The cetyltrimethylammonium bromide bilayer on GNRs is replaced with heterobifunctional PEG (COOH-PEG-SH) to serve as a biocompatible s

Hybrid nanoparticles with multi-functional capabilities of targeted infection, magnetic resonance (MR) imaging, and gene delivery are developed by fusing virus and MnMEIO magnetic nanoparticles. Their successful utilizations for in vitro target-specific MR imaging and enhanced green fluorescent protein (eGFP) gene delivery into CAR-positive cells are demonstrated.

Abstract Molecular imaging using nanoprobes with high resolution and low toxicity is essential in early cancer detection. Here we introduce a new class of smart imaging probes employing PEGylated gold nanorods (GNRs) conjugated to cRGD for specific optical imaging of α v β 3 integrins from glioblastoma. GNRs exhibiting an optical resonance peak in the near‐infrared (NIR) region were synthesized using the seed‐mediated growth method. CTAB (cetyl trimethylammonium bromide) bilayer on the GNRs was

The cancer stem cell (CSC) hypothesis postulates that cancer cells overexpressing CD44 are marked as CSCs that cause tumorigenesis and recurrence. This hypothesis suggests that CD44 is a potential therapeutic target that can interfere with CSCs qualities. MicroRNA-34a (miR-34a) is a promising candidate for CD44 repression-based cancer therapy as it has been reported to inhibit proliferation, metastasis, and survival of CD44-positive CSCs. Here, we used nanovesicles containing PLI/miR complexes (