이화여자대학교 · 생화학·유전·분자생물학
윤정파크 교수의 연구실은 암 생물학과 표적 치료 전략 개발을 중심으로, 코리세프스 균류에서 유래한 코리세프린과 이소퀴놀린 알칼로이드 등 천연물질의 항암 메커니즘을 분자 수준에서 규명하고 있습니다. 특히 세포 사멸 유도, 세포 주기 정지, 에피제네틱 조절 등 다양한 생물학적 경로를 타겟으로 하여 암 치료의 새로운 가능성을 모색하고 있습니다. 또한 남아프리카공화국의 중국 이주민 사회와 그들의 정체성, 사회적 위치에 대한 인류학적·사회학적 연구를 병행하여, 건강, 약물, 이주 간의 복합적 상호작용을 탐구하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
<i>Cordyceps</i> is a genus of ascomycete fungi that has been used for traditional herbal remedies. It contains various bioactive ingredients including cordycepin. Cordycepin, also known as 3-deoxyadenosine, is a major compound and has been suggested to have anticancer potential. The treatment of various cancer cells with cordycepin in effectively induces cell death and retards their cancerous properties. However, the underlying mechanism is not fully understood. Recent evidence has shed light o
Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest, apoptosis, and autophagy, leading to cell death. While the molecular mechanisms of these effects are not fully understood, it has been suggested that binding to nucleic acids or proteins, enzyme inhibition, and epigenetic modulation by isoquinoline alkaloids may play a role in the effects. This review discusses
Chapter 1 Introduction Chapter 2 Chapter One: Sojourners to Settlers: Early Constructions of Chinese Identity in South Africa Chapter 3 Chapter Two: Apartheid-Era Constructions: White, Non-White, and Honorary White Chapter 4 Chapter Three: The Symbolic Centre: The Influence of China, Real and Mythical Chapter 5 Chapter Four: Whitening and Upward Mobility: Shifting Race, Class, and Social Position Chapter 6 Chapter Five: Our Own Little Box: Cultural and Ethnic Identity Chapter 7 Chapter Six: Afte
South Africa is host to the largest population of Chinese on the African continent, with estimates ranging from 250,000 – 350,000. Various waves of migration from China to South Africa have resulted in the creation of diverse, multi-generational, and multi-lingual communities of Chinese. The article explores these waves of migration and then focuses on the newest Chinese migrants, mostly from rural parts of Fujian province, many of whom are settling in small, rural towns across the country. The
Non-small cell lung cancer (NSCLC) is a major subtype of lung cancer. Besides genetic and environmental factors, epigenetic alterations contribute to the tumorigenesis of NSCLC. Epigenetic changes are considered key drivers of cancer initiation and progression, and altered expression and activity of epigenetic modifiers reshape the epigenetic landscape in cancer cells. Euchromatic histone-lysine N-methyltransferase 2 (EHMT2) is a histone methyltransferase and catalyzes mono- and di-methylation a
Abstract: Increasing numbers of Chinese migrants have arrived in southern Africa over the past two decades. Perceptions of and reactions to the Chinese, however, vary from country to country and within countries. This article, based on several years of field and survey research, examines perceptions of Chinese in South Africa and Lesotho. The author argues that in addition to the global context, national political and economic realities, history, and memory shape local perceptions of China and t
Developing innovative and pervasive smart technologies that provide medical support and improve the welfare of the elderly has become increasingly important as populations age. Elderly people frequently experience incidents of discomfort in their daily lives, including the deterioration of cognitive and memory abilities. To provide auxiliary functions and ensure the safety of the elderly in daily living situations, we propose a projection-based augmented reality (PAR) system equipped with a deep
Ovarian cancer is the gynecological malignancy with the poorest prognosis, in part due to its high incidence of recurrence. Platinum agents are widely used as a first-line treatment against ovarian cancer. Recurrent tumors, however, frequently demonstrate acquired chemo-resistance to platinum agent toxicity. To improve chemo-sensitivity, combination chemotherapy regimens have been investigated. This study examined anti-tumor effects and molecular mechanisms of cytotoxicity of <i>Oldenlandia diff
This article explores existing boundaries and borders, both real and metaphorical, related to various Chinese communities in southern Africa. Starting with a discussion of the physical, territorial and often quite porous borders between South Africa and its neighbouring countries, Park then turns to the metaphorical, fluid, and constructed boundaries between various groups of Chinese, between citizen and foreigner, and between settler and sojourner. The article concludes with the suggestion that
Based on a brief review of the existing literature on knowledge transfer between Chinese and Africans, this introductory essay sheds light on the purpose, methodologies, and main findings of this special issue. Aiming to investigate the impacts of Chinese FDI projects on technology learning in Africa, a team of SAIS-CARI researchers conducted field research in six African countries. To our knowledge, this is the first time such a comprehensive analysis on China-Africa knowledge transfer has been
Cordyceps militaris is rich in adenosine derivatives, including 3'-deoxyadenosine, also known as cordycepin. It has been reported for antitumor effects, but its underlying molecular mechanism has yet to be elucidated. We investigated how adenosine derivatives exerted antitumor effects against ovarian cancer using human ovarian cancer cells and a xenograft mouse model. Treatment with adenosine derivatives effectively resulted in cell death of ovarian cancer cells through AMPK activation and subse
Chinese presence throughout the African continent has increased tremendously in the last decade, resulting in both high hopes and many serious concerns. The Chinese state news agency Xinhua reporte...
