Yoon Kyung Jeon
서울대학교 의과대학 · 의학
윤경제 교수의 연구실은 난임성 림프종, 특히 확산성 대세포 B 림프종(DLBCL)의 종양 미세환경과 면역조절 메커니즘을 중심으로 연구를 진행하고 있습니다. PD-1/PD-L1 축, 종양 관련 매크로파지(TAMs) 및 조절성 T세포(Tregs)의 역할을 규명하며 면역치료의 임상적 응용 가능성을 탐색하고 있으며, Pellino-1과 같은 신호전달 분자의 종양 유도 기전에 대해서도 기초적 기전을 규명하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
PD-L1 and PD-1 were expressed variably in DLBCLs by tumour cells and tumour-infiltrating immune cells and might be potential therapeutic targets using PD-1/PD-L1 blockade.
Tumor-associated macrophages (TAMs) and regulatory T-cells (Tregs) play an important role in the tumor microenvironment. Here, we investigated the prognostic implications of TAMs and Tregs in 165 diffuse large B-cell lymphomas (DLBCLs) using immunohistochemistry. Survival analysis was performed among 109 DLBCLs treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). An increase in CD68 (+) cells was related to improved overall survival (OS) (p = 0.033). By con
Pellino-1 is an E3 ubiquitin ligase acting as a critical mediator for a variety of immune receptor signaling pathways, including Toll-like receptors, interleukin-1 receptor and T-cell receptors. We recently showed that the Pellino-1-transgenic (Tg) mice developed multiple tumors with different subtypes in hematolymphoid and solid organs. However, the molecular mechanism underlying the oncogenic role of Pellino-1 in solid tumors remains unknown. Pellino-1-Tg mice developed adenocarcinoma in the l
