Keio University · 의학
요시후미 카스가 교수의 연구실은 임신성 당뇨병(GDM)과 그 영향에 초점을 맞춘 임상 및 분자생물학적 연구를 수행하고 있습니다. 특히 임신 중 당대사 이상이 태아의 대사 기억(epigenetic changes)과 후속 건강 이상으로 이어지는 메커니즘을 규명하고자 하며, 유전적 소인, DNA 메틸화 패atters, 그리고 산후 당역학 이상의 예측 요소를 탐색하고 있습니다. 코로나19 패안드레미크 상황에서도 임신부의 병원 방문을 최소화하는 진단 전략 개선에 기여한 바가 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Mid-trimester residual cervical length is a good predictor of preterm birth after radical trachelectomy.
Gestational diabetes (GDM) and type 2 diabetes (T2DM) share part of pathomechanism and several T2DM susceptibility genes are demonstrated to be associated with GDM. No information on the genetics of GDM, however, was available in Japanese women. In this study, T2DM risk variants (45 single nucleotide polymorphisms [SNPs] from 36 genes) identified in previous studies were genotyped using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in a cohort of 171 Japanese women
Gestational diabetes (GDM) is one of the most common perinatal complications. As pregnant women have to consume 75 g of glucose during an oral glucose tolerance test (OGTT) in order to diagnose GDM, they have to stay longer in hospitals. Since its outbreak, COVID-19 has spread all over the world. To prevent the COVID-19 infection, patients must minimize hospital visits, avoid spending long periods of time at the hospital, and limit face-to-face contact with healthcare practitioners. As a result,
This is the first report to determine the DNA methylation patterns in neonates born to mothers with E-GDM. Neonates born to mothers with GDM, who were diagnosed based on Japan Society of Obstetrics and Gynecology criteria, may not differ in DNA methylation compared with those born to normal OGTT mothers.
Clinical features and genetic variants related to impaired insulin secretion are risk factors of postpartum abnormal glucose tolerance in Japanese women with recent gestational diabetes mellitus.
The detection of epigenetic changes associated with neonatal hypoglycaemia may reveal the pathophysiology and predict the onset of future diseases in offspring. We hypothesized that neonatal hypoglycaemia reflects the <i>in utero</i> environment associated with maternal gestational diabetes mellitus. The aim of this study was to identify epigenetic changes associated with neonatal hypoglycaemia. The association between DNA methylation using Infinium HumanMethylation EPIC BeadChip and neonatal pl
Although maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) are related to fetal growth, there is a paucity of data regarding how offspring sex affects the relationship between maternal BMI in underweight mothers (pre-pregnancy BMI <18.5 kg/m2) and size for gestational age at birth. The aim of this study was to investigate the effect of offspring sex on the relationships among maternal pre-pregnancy BMI, GWG and size for gestational age at birth in Japanese underweigh
Low-birthweight (LBW; <2,500 g) babies are at a higher risk of poor educational achievement, disability, and metabolic diseases than normal-birthweight babies in the future. However, reliable data on factors that contribute to LBW have not been considered previously. Therefore, we aimed to examine the distribution of the causes for LBW. A retrospective review of cases involving 4,224 babies whose mothers underwent perinatal care at Keio University Hospital between 2013 and 2019 was conducted. Th
Our one-step TCR-M is useful for women with submucosal myoma. However, we suggest that clinicians should review and check the association between prior myomectomy locations and placenta implantation.
