Nagoya University · 의학
요시오 아카키 교수의 연구실은 장내 미생물, 장벽 기능 및 염증성 장질환의 분자 기전에 중점을 두고 있으며, 특히 다이어트 식이요법, 프로바이오틱스 및 식이섬유가 장염을 유도하는 모델에서 장내 미생물총과 단쇄지방산의 변화에 미치는 영향을 연구하고 있습니다. 또한, 박테리아 세포벽 성분의 생화학적 특성과 면역 반응 간의 상호작용, 특히 티올리제이드나 페프티도글리칸 등 구조적 성분이 염증 반응에 미치는 영향을 규명하고 있습니다. 이와 더불어, 장상피세포 모델과 동물 모델을 기반으로 병리학적 변화와 면역세포 반응의 기전을 분석하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
1. An enzyme that catalyzes hydrolysis of acetamido groups of chitin derivatives was found in the supernatant fraction of Mucor rouxii. 2. Partially O-hydroxyethylated chitin (glycol chitin) was used as a substrate in the purification and characterization of this enzyme. A 140-fold purification was obtained by means of ammonium sulfate fractionation followed by chromatography on carboxymethylcellulose and DEAE-cellulose. 3. The enzyme releases about 30% of the acetyl groups of glycol chitin, giv
The occurrence of N-nonsubstituted glucosamine residues in Bacillus cereus cell wall peptidoglycan is demonstrated and accounts for resistance of the cell walls to lysozyme. Lysozyme-resistant cell walls isolated from three strains of B.cereus indicate unusually small free muramic acid contents as analyzed in an autoanalyzer after acid hydrolysis. Over 80% of the total muramic acid was recovered from the acid hydrolysates of the peptidoglycan as disaccharides, which were identified as glucosamin
Pathogenic mechanisms responsible for inflammatory bowel disease (IBD) are poorly understood. In an IBD animal model, the oral administration of polysaccharides such as dextran sulfate sodium (DSS) induces colitis, which exhibit several clinical and histological features for IBD. However, pathogenic factors in the development of colitis remain unclear. Therefore, we investigated possible mechanisms for DSS-induced colitis, and mainly focused on biological responses from an intestinal epithelial
Article de synthese sur la structure chimique de la jonction entre le peptidoglycane et les polyosides (acides teichoiques, acides teichuroniques et autres polyosides) dans la paroi des bacteries Gram positif
Ws/Ws rats have a small deletion of the c-kit gene, and are deficient in both mucosal-type mast cells (MMC) and connective tissue-type mast cells (CTMC). In the present study we investigated the role of intestinal MMC in the development of dextran sulphate sodium (DSS)-induced experimental colitis using Ws/Ws rats. Ws/Ws and control (+/+) rats were given a 3% DSS aqueous solution orally for 10 days, and the subsequent mucosal damage was evaluated macroscopically and histologically. The mucosal m
Germinated barley foodstuff (GBF) administration has been previously reported to suppress dextran sulfate sodium (DSS)-induced experimental colitis. In this study, we investigated the roles of the intestinal microflora and short chain fatty acids (SCFAs) following administration of GBF in DSS-induced rat colitis. Sprague-Dawley rats were fed 3% (w/w of diet) DSS in GBF-diets for 5 days. The control rats were fed 3% DSS in cellulose-diets for 5 days. The administration of GBF effectively prevente
