Youngro Byun
서울대학교 약학과 · 의학
이 교수의 연구실은 생물의학적 분자 구조의 시각화 및 분석 기술 개발과 함께, 생체활성 글리코사미노글리칸 유사 물질의 기능적 응용에 중점을 두고 있습니다. 특히 RNA 구조의 시각화를 위한 웹 기반 소프트웨어 플랫폼과 헤파린 유도체를 이용한 혈전 억제 및 암 치료 응용 기술을 개발하고 있으며, 생체막을 통한 비침습적 약물 전달 체계의 설계에도 기여하고 있습니다. 이는 생물의학적 약물의 안정성과 약물 전달 효율을 향상시키는 데 초점이 맞춰져 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Visualizing RNA secondary structures and pseudoknot structures is essential to bioinformatics systems that deal with RNA structures. However, many bioinformatics systems use heterogeneous data structures and incompatible software components, so integration of software components (including a visualization component) into a system can be hindered by incompatibilities between the components of the system. This paper presents an XML web service and web application program for visualizing RNA second
Although heparin can regulate angiogenesis, tumor growth and metastasis, its clinical application, as well as that of low-molecular heparin (LMWH), for treating cancer are limited because of heparin's anticoagulant activity and risk of hemorrhages. LMWH-taurocholate conjugates (LHT7), which have low anticoagulant activity, were synthesized. The structural property of LHT was evaluated by circular dichroism and the binding affinity of LHT7 to vascular endothelial growth factor 165 (VEGF(165)) was
Macromolecular therapeutics, in particular, many biologics, is the most advancing category of drugs over conventional chemical drugs. The potency and specificity of the biologics for curing certain disease made them to be a leading compound in the pharmaceutical industry. However, due to their intrinsic nature, including high molecular weight, hydrophilicity and instability, they are difficult to be administered via non-invasive route. This is a major quest especially in biologics, as they are f
