Yuichiro Kobayashi 교수

Metal-ligand interactions with various proteins form in vivo metal assemblies. In recent years, metallosupramolecular approaches have been utilized to forge an assortment of fascinating two- and three-dimensional nano-architectures and macroscopic materials, such as metal-ligand coordination polymeric materials, have promise in artificial systems. However to the best of our knowledge, the self-assembly of macroscopic materials through metal-ligand interactions has yet to be reported. Herein we d

Ring-opening polymerization of 1,6-anhydro-β-<sc>d</sc>-glucose in one-dimensional nanochannels of a porous coordination polymer gave a quasi-linear polyglucose without cross-linking.

Polymeric materials were prepared by cross-linking them with two independent non-covalent interactions, namely hydrogen bonding and metal–ligand interactions.

Polymerization of monosaccharide monomers usually suffers from the production of polysaccharides with ill-defined structures because of the uncontrolled random reactions among many reactive hydroxyl groups on saccharide monomers. In particular, rational synthesis of polysaccharides with porosity approximating molecular dimensions is still in its infancy, despite their usefulness as drug carriers. Here, we disclose an efficient synthetic methodology for the preparation of polysaccharides with con

We demonstrated a feasible method for providing polyrotaxanes (PRxs) with a controlled threading ratio of cyclic molecules and chain length of linear polymers by extending the linear polymers in the pseudo-PRx. This method gave PRxs with a lower threading ratio and a higher mobility of cyclic molecules compared to usual methods used previously with a high threading ratio. In addition, our PRx improved the thermal stability of the linear polymers in PRx despite the low threading ratio.

Thermal ring-opening polymerization of the unsymmetrically substituted [1]ferrocenophane was performed in one-dimensional nanochannels of porous coordination polymers (PCPs). In contrast to conventional thermal polymerization in bulk, formation of cyclic polymer was inhibited in the channels. In addition, the tacticity of the resulting polymer was dependent on the pore size of PCPs.

A supramolecular hydrogel was prepared by the introduction of host-guest interactions between polyrotaxane (PRx) having guest parts and poly(acrylamide) with cyclodextrin hosts. Although the chemically cross-linked poly(acrylamide) hydrogels did not adhere to each other at the cut ends, the supramolecular hydrogels adhered to each other strongly even enduring their own weight. The recovery speed of rupture stress for the supramolecular hydrogels containing PRx was faster than that without PRx du

We report the first preparation of a monoclonal antibody (mAb) that can immobilize a palladium (Pd)-complex. The allylic amination reaction using a supramolecular catalyst consisting of the Pd-complex and mAb selectively gives the (R)-enantiomer product with an enantiomeric excess (ee) of 98 ± 2%. This is in sharp contrast to the reaction catalyzed by a conventional Pd-catalyst (ee < 2%).

We report the first preparation of a supramolecular polysulfide polymer, which is a polyrotaxane containing sulfur-styrene copolymer and methylated α-cyclodextrins (TMαCDs) as linear and cyclic molecules, respectively (SPRx). Compared to the sulfur-styrene copolymer prepared by a copolymerization method typically used to synthesize polysulfide polymers, the environmental and thermal stabilities of SPRx are significantly improved because the polysulfide polymer is covered with TMαCD.

We report a new methodology to synthesize a polysulfide polymer via a supramolecular chemistry approach.

Enzymes play a vital role in catalysing almost all chemical reactions that occur in biological systems. Some enzymes must form complexes with non-protein molecules called cofactors to express catalytic activities. Although the control of catalytic reactions via apoenzyme-cofactor complexes has attracted significant attention, the reports have been limited to the microscale. Here, we report a system to express catalytic activity by adhesion of an apoenzyme gel and a cofactor gel. The apoenzyme an

We prepared enzyme-immobilized hydrogels and investigated the effects of the cross-linking density and polymer properties on their oxidation reaction rate. The oxidation rate of enzyme-immobilized hydrogels increased as the cross-linking density in the hydrogels increased. In addition, we controlled the oxidation rate using hydrogels exhibiting an appropriate interaction with a decoy molecule in the hydrogel.

Abstract We report the first preparation of a supramolecular polysulfide polymer using metal‐ligand interactions. The supramolecular polysulfide polymer was prepared by introducing 2,2’‐bipyridine (bpy) at both ends of linear sulfur and linking the bpy with Cu 2+ . The molecular weight of the supramolecular polysulfide polymer was higher than polysulfide polymer obtained via conventional polymerization. Disassembly and re‐assembly of the supramolecular polysulfide polymers were controlled by de‐