Kyoto University · 의학
유지 나카모토 교수의 연구실은 주로 정성적 및 정량적 PET 영상 분석을 중심으로, 암 진단과 재활성화 모니터링을 위한 정밀 의학 기반 영상 기술 개발에 집중하고 있습니다. 특히 FDG-PET/CT 영상에서 림프절, 갑상선, 췌장 및 난소암과 같은 특정 해부학적 영역의 대사 활성과 영상 오차 요인을 분석하여 진단 정확도를 향상시키는 데 초점을 맞추고 있습니다. 또한, 영상 기반 정량 분석의 정확성을 높이기 위한 캘리브레이션, 인식 오차 보정, 대조제로 인한 영향 분석 등 기초 영상 물리학적 문제 해결에도 기여하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Intense FDG uptake was usually observed in the palatine tonsils, lingual tonsils, and soft palate, whereas uptake in the major salivary glands was variable.
The current data suggest that delayed FDG-PET scanning at 2 hours postinjection may contribute to differentiation between malignant and benign lesions in the pancreas.
Although quantitative radioactivity values are generally comparable between CT- and germanium-corrected emission PET images, CT-based attenuation correction produced radioactivity concentration values significantly higher than the germanium-based corrected values. These effects, especially in radiodense tissues, should be noted when using and comparing quantitative PET analyses from PET and PET/CT systems.
Our preliminary data suggest that whole-body PET with FDG can be a complementary modality for following up patients who have had ovarian cancer, especially patients believed to be at risk for recurrence.
High concentrations of a contrast agent caused considerable overestimation of apparent tracer activity in phantom studies; however, the emission bias was relatively modest in vivo, except in areas with very high contrast agent concentrations.
PURPOSE: To retrospectively evaluate lesion findings at computed tomography (CT) performed as part of a combined positron emission tomography (PET)/CT examination in patients suspected of having metastatic bone lesions—lesions that were detected with fluorine 18 fluorodeoxyglucose (FDG) PET as part of the same examination—and to correlate the CT and FDG PET findings. MATERIALS AND METHODS: This HIPAA-compliant study had institutional review board approval, and the need for patient informed conse
Our preliminary data indicate that NIS-based gene therapy may be applied by concentrating a lethal dose of radiation in tumor cells in vivo, but further investigation is necessary to determine a method of maintaining radioiodine in the cells to allow greater therapeutic effects.
The most frequent pattern of detectable bone metastases with FDG-PET imaging was multiple foci of intense uptake. PET revealed more lesions than did bone scanning, independent of the type of cancer or location of bone involvement, in patients who were accurately diagnosed by FDG-PET imaging.
