Keio University · 의학
Yuki Enoki 교수의 연구실은 만성 신장질환(CKD)과 관련된 근육 위축(사크레노피아)의 분자 기전을 규명하고 있으며, 특히 유독성 대사물질인 인도올 황산염(IS)이 미토콘드리아 기능 저하와 산화 스트레스를 유도하여 근육 손상을 유발하는 메커니즘을 중심으로 연구를 진행하고 있습니다. 또한, apelin-Apj 경로와 같은 내재적 보호 시스템의 기능 저하가 근육 위축에 기여하는지를 밝혀내고, 이에 대한 표적 치료 전략 개발에도 주력하고 있습니다. 최근에는 항생제의 항산화 작용과 면역 조절 기능을 활용한 폐 감염 치료 전략에 대해서도 연구를 확장하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Skeletal muscle atrophy, referred to as sarcopenia, is often observed in chronic kidney disease (CKD) patients, especially in patients who are undergoing hemodialysis. The purpose of this study was to determine whether uremic toxins are involved in CKD-related skeletal muscle atrophy. Among six protein-bound uremic toxins, indole containing compounds, indoxyl sulfate (IS) significantly inhibited proliferation and myotube formation in C2C12 myoblast cells. IS increased the factors related to skel
Our results indicate that IS induces mitochondrial dysfunction in skeletal muscle cells and provides a potential therapeutic strategy such as IS-targeted and mitochondria-targeted interventions for treating CKD-induced muscle atrophy and decreased exercise endurance.
Reactive oxygen species (ROS) and nitric oxide (NO) are major pathogenic molecules produced during viral lung infections, including influenza. While fluoroquinolones are widely used as antimicrobial agents for treating a variety of bacterial infections, including secondary infections associated with the influenza virus, it has been reported that they also function as anti-oxidants against ROS and as a NO regulator. Therefore, we hypothesized that levofloxacin (LVFX), one of the most frequently u
This meta-analysis is the first study that clarifies the usefulness of an alcohol-based CHG solution with a 0.5 per cent or higher CHG concentration for surgical skin preparation to prevent SSI.
This systematic review and meta-analysis compares the efficacy of daptomycin and vancomycin in adult patients with bacteremia by methicillin-resistant Staphylococcus aureus (MRSA) with vancomycin minimum inhibitory concentration (MIC) > 1 µg/mL. We searched the PubMed, Web of Science, Cochrane Library, and ClinicalTrials.gov databases on 12 May 2020. All-cause mortality (primary outcome) and treatment success rates were compared and subgroups stratified by infection source risk level and method
This study demonstrated for the first time the association of the Apj endogenous ligand-uraemic toxin axis with skeletal muscle atrophy in CKD and the utility of therapeutic targeting of the apelin-Apj system.
Prior micafungin use increased the risk of <i>C. parapsilosis</i> and the MIC > 0.06 μg/mL of micafungin in non-<i>parapsilosis Candida</i> species. Since there are only a few antifungal options, further antifungal stewardship considering azole antifungal agents use is required.
• Remdesivir is proposed as a therapeutic for COVID-19 • Clinical improvement after remdesivir was higher compared with placebo • Remdesivir tended to reduce patient mortality rate, but this was not significant
The combined use of daptomycin and statins were significant risk factors for the incidence of CPK elevation defined as levels ≥ULN or ≥5× ULN and rhabdomyolysis.
