北海道大学 · Biochemistry, Genetics and Molecular Biology
Yuma Yamada 교수의 연구실은 미토콘드리아를 표적으로 하는 혁신적 치료 전략 개발에 초점을 맞추고 있습니다. 특히 미토콘드리아 이식 치료, 미토콘드리아 표적 약물 전달 시스템(MITO-Porter 등), 그리고 유전자 치료를 통해 유전적 미토콘드리아 질환을 치료하는 데 주력하고 있으며, 심장질환, 뇌질환 등 다발성 장기 손상과 관련된 질환에 대한 신약 개발을 추진하고 있습니다. 특히 미토콘드리아 내부에 정밀하게 약물을 또는 유전자를 전달하는 나노기술 기반의 치료 전략이 핵심입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Mitochondrial transplantation therapy is an innovative strategy for the treatment of mitochondrial dysfunction. The approach has been reported to be useful in the treatment of cardiac ischemic reperfusion injuries in human clinical trials and has also been shown to be useful in animal studies as a method for treating mitochondrial dysfunction in various tissues, including the heart, liver, lungs, and brain. On the other hand, there is no methodology for using preserved mitochondria. Research int
Here, we report on validating a mitochondrial gene therapy by delivering nucleic acids to mitochondria of diseased cells by a MITO-Porter, a liposome-based carrier for mitochondrial delivery. We used cells derived from a patient with a mitochondrial disease with a G625A heteroplasmic mutation in the tRNA<sup>Phe</sup> of the mitochondrial DNA (mtDNA). It has been reported that some mitochondrial gene diseases are caused by heteroplasmic mutations, in which both mutated and wild-type (WT) genes a
There have been many reports on the relationship between mitochondrial oxidative stress and various types of diseases. This review covers mitochondrial targeting photodynamic therapy and photothermal therapy as a therapeutic strategy for inducing mitochondrial oxidative stress. We also discuss other mitochondrial targeting phototherapeutic methods. In addition, we discuss anti-oxidant therapy by a mitochondrial drug delivery system (DDS) as a therapeutic strategy for suppressing oxidative stress
Correction for 'The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter' by Satrialdi et al., Chem. Commun., 2020, 56, 1145-1148, DOI: 10.1039/C9CC08563G.
