The University of Tokyo · 의학
Yutaka Osuga 교수의 연구실은 난소질환, 특히 난소내막증의 면역학적 기전과 병태생리학을 중심으로 연구를 진행하고 있습니다. 특히 면역세포 기능 이상, 특히 자연살해세포와 T세포의 기능 저하, 그리고 병변 형성에 관여하는 유전자 발현 변화에 초점을 맞추고 있습니다. 또한, 호르몬 수용체의 기능 이상이 질환 발현에 미치는 영향을 분자생물학적 접근을 통해 규명하고 있습니다. 이와 같은 기초 연구는 난소내막증의 조기 진단 및 새로운 치료 전략 개발에 기여하고자 합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Endometriosis is a disease characterized by the presence of endometriotic tissue outside the uterine cavity. Although its pathogenesis remains to be elucidated, immune status is suggested to play an important role in the initiation and the progression of the disease. In particular, immune cells in lymphoid lineage that comprised T and B lymphocytes and natural killer cells play essential roles in determining either accept or reject survival, implantation, and proliferation of endometrial and end
Endometriosis is a disease that causes the health of women of reproductive age to deteriorate. The implantation theory is the most widely accepted pathogenesis of the disease, although many points remain poorly understood concerning this theory. According to this theory, regurgitated endometrial debris has to go through various sequential events for the disease to develop. Recent studies have elucidated several aspects of these events. A remarkably reduced gene expression of GnRH II and an incre
Gonadotropin receptors are unique members of the seven-transmembrane (TM), G protein-coupled receptor family with a large extracellular (EC) sequence forming the high-affinity ligand binding domain. In a patient with Leydig cell hypoplasia, we identified a mutant LH receptor that is truncated at TM5. This protein retains limited ligand binding ability but cannot mediate cAMP responses. To study interactions between receptor fragments defective in either ligand binding or signal transduction, we
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