Kyushu University · 의학
Zulvikar Syambani Ulhaq 교수의 연구실은 신경발달 및 신경질환에서 호르몬(특히 에스트로겐)과 염증성 사이토카인(IL-6, IL-10)의 역할을 중심으로 연구를 진행하고 있습니다. 특히 어류에서의 뇌 아로마타제(AroB) 기능과 성호르몬이 신경세포 형성에 미치는 영향, 그리고 인체에서 IL-6 유전자 다형성과 녹내장, 파킨슨병 등 신경안과질환 간의 연관성에 초점을 맞추고 있습니다. 또한, 염증 반응과 호르몬 조절의 상호작용이 뇌 및 눈의 병리에 어떻게 기여하는지 기초 및 임상적 관점에서 종합적으로 탐구하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Teleost fish are known to express two isoforms of P450 aromatase, a key enzyme for estrogen synthesis. One of the isoforms, brain aromatase (AroB), <i>cyp19a1b</i>, is highly expressed during early development of zebrafish, thereby suggesting its role in brain development. On the other hand, early development of serotonergic neuron, one of the major monoamine neurons, is considered to play an important role in neurogenesis. Therefore, in this study, we investigated the role of AroB in developmen
Interleukin-6 (IL-6) is one of the key regulators behind the inflammatory and pathological process associated with ophthalmic diseases. The role of IL-6-174 G/C polymorphism as well as intraocular IL-6 levels among various eye disease patients differ across studies and has not been systematically reviewed. Thus, this study aims to provide a summary to understand the relationship between IL-6 and ophthalmic disease. In total, 8,252 and 11,014 subjects for IL-6-174 G/C and intraocular levels of IL
Treacher Collins syndrome (TCS, OMIM: 154500) is a rare congenital craniofacial disorder that is caused by variants in the genes TCOF1, POLR1D, POLR1C, and POLR1B. Studies on the association between phenotypic variability and their relative variants are very limited. This systematic review summarized the 53 literatures from PubMed and Scopus to explore the potential TCS genotype-phenotype correlations with statistical analysis. Studies reporting both complete molecular genetics and clinical data
Anxiety symptoms and disorders are common problems associated with ophthalmic disease patients. Thus, comprehensive and appropriate treatments are necessary for treating anxiety symptoms and disorders among ophthalmic disease patients.
Abstract Background Strong evidence supports the involvement of inflammation processes in the development and progression of Parkinson’s disease (PD), where increasingly correlations have been identified between genetic variations in inflammation-related genes and PD. However, data varies between studies. Therefore, we conducted a meta-analysis to clarify associations between inflammation-related gene polymorphisms and PD risk. Methods All studies were identified through online databases. Pooled
The balance between IL-6 and IL-10 serum levels is potentially useful in discriminating POAG severity.
