东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Masaki Igarashi's research lab focuses on the molecular mechanisms underlying aging and age-related diseases, with a central emphasis on the NAD+/SIRT1/mTORC1 signaling axis. The lab investigates how NAD+ metabolism influences stem cell function and tissue homeostasis during aging, exploring therapeutic interventions such as NAD+ precursors (e.g., NR, NMN) to promote regenerative capacity. Additionally, the lab examines lipid metabolism in atherosclerosis, particularly the role of neutral cholesterol ester hydrolase (NCEH1) in reverse cholesterol transport and foam cell formation. These studies integrate translational approaches from preclinical models to human clinical trials, aiming to develop novel strategies for healthy aging and metabolic disease prevention.
Professor Daigo Terutsuki's research lab specializes in bio-hybrid electronic systems, focusing on the integration of living biological components—such as insect cells and olfactory receptors—into advanced electronic devices for highly sensitive and selective detection of odorant molecules. The lab develops innovative biosensors, including field-effect transistor-based odorant sensors and soft organic electrodes for neuromodulation, leveraging biocompatible materials and CMOS-compatible fabrication processes. A key research direction involves creating intelligent small drones equipped with bio-inspired sensors for real-time environmental monitoring, security applications, and search-and-rescue operations. The lab also pioneers 3D-printed microfluidic systems for life sciences, emphasizing bubble-free perfusion to support long-term live-cell imaging.
Professor Yusheng Wang's research lab specializes in underwater sensing and navigation, focusing on advanced 3D mapping, inertial navigation, and acoustic imaging technologies. The lab develops innovative solutions for underwater environment perception using acoustic cameras and inertial measurement units (IMUs), particularly in challenging conditions such as turbid water and low visibility. Key research directions include 3D reconstruction from 2D acoustic images, error compensation in pedestrian inertial navigation, and fiducial marker systems for underwater robotics and augmented reality. The lab combines probabilistic mapping, sensor fusion, and real-world experimentation to enhance the accuracy and robustness of underwater robotic systems.
Professor Xue Qu's research lab specializes in agricultural economics and food security, with a primary focus on rice harvest loss reduction in China. The lab investigates the impacts of mechanization, farm scale, and agricultural outsourcing services on post-harvest losses, emphasizing the role of institutional and behavioral factors such as moral hazard and information asymmetry. Using large-scale survey data and advanced econometric methods—including quantile regression, Tobit models, and mediation analysis—the lab explores how farming practices, technology adoption, and policy interventions influence loss mitigation. The research also addresses the socioeconomic disparities between specialized and part-time farmers, offering evidence-based policy recommendations for sustainable food systems.
Professor Manabu Tsukada's research lab specializes in intelligent transportation systems, with a focus on vehicle-to-everything (V2X) communication, cooperative perception, and networked infrastructure for autonomous vehicles. The lab develops open-source software platforms such as AutoC2X and OpenC2X to enable real-time sensor data sharing and interoperability between vehicles and roadside units. Key research directions include geographic routing protocols (e.g., C2CNet), IPv6 integration in vehicular networks, and multi-router management for mobile networks (NEMO), aiming to enhance safety, efficiency, and connectivity in mixed-traffic environments. The lab emphasizes practical deployment through field experiments and testbed evaluations, particularly in cooperative awareness and infrastructure-based perception systems.
Professor Takamichi Ishii's research lab focuses on regenerative medicine and liver tissue engineering, with a primary emphasis on deriving functional hepatocytes from human pluripotent stem cells (hESCs and hiPSCs) for therapeutic applications. The lab investigates the molecular mechanisms governing hepatic differentiation, optimizes culture conditions using extracellular matrix and growth factors, and develops bioengineered liver constructs using decellularized scaffolds. A key direction involves evaluating the therapeutic potential of stem cell-derived hepatocytes in liver injury models and exploring the role of specific cell subpopulations, such as CD9S+ cells, in liver cancer progression and metastasis.
Professor Takeshi Noda's research lab specializes in virology and structural biology, focusing on the assembly and morphogenesis of negative-sense RNA viruses, particularly Ebola virus and influenza A virus. The lab employs advanced electron microscopy techniques, including electron tomography, to elucidate the three-dimensional architecture of viral ribonucleoprotein (RNP) complexes and viral structural proteins at the nanoscale. Key research directions include understanding the role of viral nucleoproteins in forming helical nucleocapsid structures, the mechanisms of viral particle budding, and the structural basis of genome packaging in segmented viruses. The lab also investigates the interplay between viral proteins and host components during virion formation, providing insights into viral replication and pathogenesis.
Professor Patrick Ocheja's research lab specializes in the intersection of blockchain technology and education, focusing on decentralized systems for secure, transparent, and portable learning records. The lab explores blockchain-based platforms like the Blockchain of Learning Logs (BOLL) to enhance learner mobility, improve data portability, and support advanced learning analytics beyond traditional transcripts. Research directions include the design of smart contract-enabled systems for managing educational credentials, visualization of academic data on blockchains, and the integration of blockchain with existing educational technologies. The lab also investigates the broader implications of blockchain in educational ecosystems, including institutional collaboration, data privacy, and long-term adoption trends.
Professor Kazunori Sugiyasu's research lab specializes in the design and fabrication of advanced supramolecular and functional materials for energy conversion and optoelectronic applications. The lab focuses on creating hierarchical nanostructures—such as organogels, self-assembled fibrils, and helical silica nanostructures—using dynamic noncovalent interactions to achieve precise control over energy and charge transport. Key research directions include light-harvesting systems with energy gradient architectures, self-sorting supramolecular assemblies for photovoltaic devices, and covalently modified conjugated polymers with enhanced charge mobility. The lab also explores bioinspired strategies to achieve complex, cooperative functionality in synthetic systems.
Professor Christopher C. Y. Yang's research lab specializes in learning analytics, educational technology, and intelligent systems for personalized learning. The lab focuses on enhancing student engagement and learning outcomes through data-driven approaches such as e-book usage analysis, learning footprint management, and AI-powered educational recommendations. Key research directions include the development of adaptive learning systems, retrieval-augmented generation (RAG) for programming education, and machine learning models for ranking educational content based on student behavior and performance.
Professor Kiyotaka Onitsuka's research lab specializes in the design and synthesis of novel organometallic complexes for catalysis and polymerization. His group focuses on the development of chiral and heterobimetallic complexes—particularly palladium-platinum and ruthenium-based systems—that enable highly selective transformations, including enantioselective allylic substitutions and living polymerizations of isocyanides. The lab is known for pioneering the use of planar-chiral ligands and μ-ethynediyl-bridged dinuclear complexes to achieve control over stereochemistry and polymer architecture. Their work bridges molecular catalyst design with the creation of functional polymers and chiral materials.
Professor Tetsuya Matsubayashi's research lab specializes in comparative politics, public policy, and political behavior, with a focus on how demographic diversity, institutional structures, and economic conditions shape policy outcomes and citizen political attitudes. The lab investigates the interplay between racial and socioeconomic diversity, electoral systems, and policy liberalism, as well as the psychological and behavioral impacts of political representation and economic crises on mental health and suicide rates. A central theme is understanding how contextual factors—such as state size, decentralization, and school calendars—influence democratic support and policy responsiveness.
Professor Atsunori Ikezawa's research lab specializes in advanced energy storage materials, with a primary focus on solid-state batteries and electrochemical energy conversion systems. The lab investigates ion transport mechanisms at solid-solid interfaces, particularly in all-solid-state lithium-ion batteries and aqueous proton batteries, using innovative in situ characterization techniques such as operando X-ray diffraction and four-electrode electrochemical cells. Key research directions include the development of high-performance electrode materials—such as Li4Ti5O12, MoO3, and NiFe-LDHs—and understanding degradation mechanisms in zinc-based batteries to enhance cyclability and stability. The lab also explores electrocatalytic processes like oxygen reduction and evolution reactions in model systems relevant to metal-air batteries.
Professor Nozomi Nishizawa's research lab specializes in spin-photonic devices and circularly polarized light (CPL) technologies, focusing on the development of spin-polarized light-emitting diodes (spin-LEDs) and spin-photodetectors for practical, room-temperature applications. The lab pioneers electrically driven CPL generation and control using spin-tunnel junctions with crystalline AlOx barriers, enabling high-purity circular polarization without external magnetic fields. A key research direction involves applying these spin-photonic devices to non-invasive, in vivo biomedical diagnostics—particularly for early cancer detection through polarization-sensitive light scattering in tissues. The lab also explores novel device architectures, such as dual spin-injection electrodes for dynamic polarization switching and tunable CPL emission, advancing integration and functionality in compact, monolithic systems.
Professor Ryota Kobayashi's research lab specializes in the design and development of soft robotics, with a focus on tensegrity structures and advanced artificial muscles. The lab explores modular, compliant robotic systems that can adapt to unknown and complex environments—such as caves or space—through active deformation mechanisms like stretching, bending, and torsion. A key emphasis is placed on enhancing the durability and performance of thin McKibben muscles and novel muscle arrangements, such as the '4/3 muscle winding' and parallel-configured artificial muscles, to enable high-force, high-efficiency actuation. The lab also investigates bio-inspired actuation principles, such as ratchet-based motion, to achieve high work output in soft mechatronic systems.
Professor Yuriko Osakabe's research lab focuses on the molecular and cellular mechanisms underlying plant abiotic stress responses, with a central emphasis on abscisic acid (ABA) signaling, ion transport regulation, and stress-adaptive growth. The lab investigates receptor-like kinases, potassium transporters, and proton pumps as key regulators of stress tolerance and homeostasis, particularly under drought and salinity conditions. Using advanced genetic and genome-editing tools such as CRISPR/Cas9 with tru-gRNAs, the lab aims to dissect signaling networks and develop stress-resilient crops. Their work bridges plant physiology, signal transduction, and biotechnological applications for sustainable agriculture.
Professor Takeshi Kawabe's research lab focuses on the immunological mechanisms governing T cell homeostasis, particularly the development, differentiation, and functional heterogeneity of memory-phenotype (MP) CD4⁺ T cells. The lab investigates how homeostatic proliferation and cytokine signals—such as IL-7 and IL-12—drive the generation of innate-like effector functions in MP T cells, with a special emphasis on T-bet-high subsets involved in rapid immune responses. Their work also explores organ-specific T cell responses, especially in mucosal tissues like the gut, and the regulation of FcεR2/CD23 in immune cells. These studies contribute to understanding immune memory, autoimmunity, and allergic inflammation at the molecular and cellular levels.
Professor Hao Wang's research lab specializes in advanced nanomaterials and their applications in energy, biomedicine, and environmental science. Key research directions include the design of functional nanomaterials such as spin-glass systems in magnetic oxides, polymer-functionalized graphene for sensing and catalysis, and near-infrared photosensitizers for biomedical imaging and therapy. The lab also focuses on molecularly engineered materials for protein detection and early diagnosis of neurodegenerative diseases using fluorescence-based sensor arrays and machine learning.
Professor Yoshitaka Sato's research lab focuses on viral-host interactions, particularly the molecular mechanisms by which viruses such as Epstein-Barr virus (EBV) manipulate host cellular pathways to facilitate their persistence and replication. The lab investigates key tumor suppressor and transcriptional regulators—especially p53 and C/EBPα—highlighting their post-translational modifications (e.g., phosphorylation, ubiquitination, sumoylation) in viral immune evasion and cellular differentiation. A central theme is understanding how viral proteins like BZLF1 subvert host tumor suppressor networks to promote lytic reactivation and immune escape. The lab integrates virology, molecular biology, and systems-level approaches such as RNA-seq to dissect dynamic host transcriptional responses during viral infection.
Professor Takashi Ishida's research lab focuses on the immunological mechanisms underlying T-cell neoplasms, particularly adult T-cell leukemia/lymphoma (ATLL), with a central emphasis on the role of CC chemokine receptor 4 (CCR4) in tumor immune evasion and microenvironment modulation. The lab investigates CCR4 as a therapeutic target, exploring antibody-based therapies such as mogamulizumab and novel treatment strategies combining targeted agents with chemotherapy. Research also extends to understanding regulatory T-cell-like functions of tumor cells and the tumor microenvironment in lymphoid malignancies and Hodgkin lymphoma. The lab integrates clinical immunology, molecular oncology, and translational research to develop effective, targeted therapies for aggressive T-cell lymphomas.
