Nagoya University · 의학
히로시게 후지시로 교수의 연구실은 루이 body 질환, 특히 데미언스와 루이 병(DLB) 및 파킨슨병(PD)의 병리학적 기반과 조기 진단 전략을 중심으로 연구를 진행하고 있습니다. 주로 신경퇴행성 질환의 초기 증상인 냄새 인지 장애, 수면 행동 장애(RBD), 자율신경계 이상 등 병리학적 변화 이전에 나타나는 임상 징후들을 규명하고 있으며, 영상학적(예: FDG-PET) 및 조직학적(예: 타이로신 히드록실라제 면역형광) 기법을 통해 병리적 변화의 시기와 진행 양상을 분석하고 있습니다. 특히, 병리학적 진단 기준의 타당성과 조기 발견 전략의 정교화를 목표로 하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Attention has been drawn to cardiac sympathetic denervation in Parkinson's disease (PD) based on clinical studies using [123I] metaiodobenzylguanidine scintigraphy; however, the histologic correlates and time course of cardiac sympathetic denervation are poorly understood. To address these issues, we used tyrosine hydroxylase (TH) immunohistochemistry to detect cardiac sympathetic nerve fibers in the epicardium of 4 normal controls, 11 cases with incidental Lewy bodies (iLBs), and 14 cases of PD
There is limited information on the validity of the pathologic criteria of the Third Consortium on Dementia with Lewy bodies (CDLB), and none are based on prospectively diagnosed cases. In this study, the core clinical features of dementia with Lewy bodies (DLB) and the suggestive clinical feature of rapid eye movement sleep behavior disorder were assessed using a battery of standardized clinical instruments in 76 patients with the clinical diagnosis of either DLB or Alzheimer disease. At autops
Dementia with Lewy bodies (DLB) is defined pathologically as neurodegeneration associated with Lewy bodies (LB). LB-related symptoms, including olfactory dysfunction, dysautonomia, and mood and sleep disorders, are increasingly recognized as clinical signs that enable the early detection of DLB, because these symptoms often antedate dementia by years or even decades. It remains unknown if the clinical history of LB-related symptoms is sufficient for the prodromal state of DLB to be suspected in
Dementia with L ewy bodies ( DLB ) is the second most common neurodegenerative dementing disorder after A lzheimer's disease ( AD ), but there is limited information regarding the prodromal DLB state compared with that of AD . P arkinson's disease ( PD ) and DLB share common prodromal symptoms with L ewy body disease ( LBD ), allowing us to use a common strategy for identifying the individuals with an underlying pathophysiology of LBD . Dysautonomia, olfactory dysfunction, rapid eye movement sle
These variations in [(18) F]-FDG PET scans raise the possibility that the specific pattern of CMRglc reduction may predict developing DLB in patients with idiopathic RBD. Further follow-up studies are needed, particularly on patients with diffuse occipital hypometabolism.
The clinical features of the genetically determined forms of familial Parkinson's disease (PD) have been described in multiple reports, but there have been few comparative neuropathologic studies. Five familial PD cases, with mutations in SNCA, were matched for age, sex, and Alzheimer type pathology with sporadic PD cases. Immunohistochemistry for phospho-tau and α-synuclein was performed in 8 brain regions. The frequency of tau pathology and the morphologic features of α-synuclein pathology in
Glucose hypometabolism in the primary visual cortex is commonly associated with the clinical features of DLB regardless of cognitive conditions. Continued follow-up of these patients without dementia with the metabolic pattern is warranted to determine if they represent the prodromal state of DLB.
