Hyun Sil Kim
연세대학교 의예과 · 의학
Hyun Sil Kim 교수의 연구실은 종양 미세환경과 대사 재편에 초점을 맞춘 생물의학적 연구를 수행하고 있습니다. 특히 암세포의 생존과 전이를 조절하는 전사인자인 Snail이 미토콘드리아 지방산 산화 및 에너지 대사 경로를 어떻게 조절하는지에 대한 분자 기전을 규명하고 있으며, 이와 관련해 ATP와 NADPH 생성을 조절하는 핵심 대사 유전자들에 대한 연구를 진행하고 있습니다. 또한, 면역세포와 상피세포의 항원 제시 메커니즘, 특히 CD1d 분자의 비-β2-미크로글로불린 의존적 발현 방식에 대해서도 기초 면역학적 기전을 탐구하고 있습니다. 이처럼 대사 재편과 세포 운명 전환을 연결하는 분자 기전을 중심으로 암 치료 전략 개발에 기여하고자 합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
CD1d is a major histocompatibility complex class I-like molecule that exhibits a distinct antigen processing pathway that functions in the presentation of hydrophobic antigens to T cells. CD1d has been previously shown to be expressed on the cell surface of human intestinal epithelial cell lines in vivo and a transfected cell line in vitro independently of beta2-microglobulin (beta2m). To define the relationship between CD1d and beta2m and characterize the biochemical structure of CD1d in the ab
Fibrosis is presented in various physiologic and pathologic conditions of the salivary gland. Transforming growth factor beta (TGF-β) pathway has a pivotal role in the pathogenesis of fibrosis in several organs, including the salivary glands. Among the TGF-β superfamily members, TGF-β1 and 2 are pro-fibrotic ligands, whereas TGF-β3 and some bone morphogenetic proteins (BMPs) are anti-fibrotic ligands. TGF-β1 is thought to be associated with the pro-fibrotic pathogenesis of sialadenitis, post-rad
Despite the importance of mitochondrial fatty acid oxidation (FAO) in cancer metabolism, the biological mechanisms responsible for the FAO in cancer and therapeutic intervention based on catabolic metabolism are not well defined. In this study, we observe that Snail (SNAI1), a key transcriptional repressor of epithelial-mesenchymal transition, enhances catabolic FAO, allowing pro-survival of breast cancer cells in a starved environment. Mechanistically, Snail suppresses mitochondrial ACC2 (ACACB
The purpose of this study was to investigate the current status of international marriage migrant women living in Daegu and Kyungpook area, and to identify the impacts of social support and life satisfaction on their depression in this population. Methods: Research objectives were accomplished by conducting an anonymous questionnaire survey with 173 international marriage migrant women. Data were analyzed using descriptive analysis, Pearson correlation coefficients and stepwise multiple regressi
In this paper, the sound transmission loss (STL) of thin double plates with an air cavity between them in a rigid duct is considered using an analytical approach. The vibration motion of the plate and sound pressure field are expanded in terms of an infinite series of the modal functions. Under the plane wave condition, a low frequency solution is derived by including the first few symmetric modes. It is determined that the peak frequencies of the double plates coincide with those of each single
Efficient catabolic metabolism of adenosine triphosphate (ATP) and reduced nicotinamide adenine dinucleotide phosphate (NADPH) is essentially required for cancer cell survival, especially in metastatic cancer progression. Epithelial-mesenchymal transition (EMT) plays an important role in metabolic rewiring of cancer cells as well as in phenotypic conversion and therapeutic resistance. Snail (SNAI1), a well-known inducer of cancer EMT, is critical in providing ATP and NADPH via suppression of sev
