성균관대학교 · 의학
정훈양 교수의 연구실은 심부전, 특히 심부전성질환에서의 미소혈관 기능 이상과 심각한 순환기 부전의 기전 및 치료 전략을 중심으로 연구를 진행하고 있습니다. 특히 심부전성질환(HFpEF) 환자에서 미소혈관 기능 이상의 병태생리학적 기전과 예후 연관성을 규명하며, 심장마비 및 난치성 충격 환자에서 ECMO를 포함한 기계적 순환지원의 적응 및 예후 요인을 분석하고 있습니다. 이는 임상에서의 정밀의료 및 환자 선택 기준 마련에 기여하고자 하는 목적이 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Coronary microvascular dysfunction is common in patients with HFpEF and is caused equally by endothelium-dependent and independent mechanisms, but the presence of microvascular dysfunction cannot be identified from clinical markers and co-morbidities alone. Patients with HFpEF and endothelium-independent microvascular dysfunction display worse diastolic dysfunction and outcomes.
Survival to hospital discharge remained low in adult patients with refractory septic shock despite ECMO support. Our findings suggest that implantation of ECMO during refractory septic shock could be considered in patients with severe myocardial injury but should be avoided in patients who have received CPR.
Survival rate for ECPR in the setting of OHCA remains poor. Our findings suggest that ECMO implantation should be very carefully considered in highly selected patients who had OHCA with little no-flow time and a reversible cause.
The in-hospital mortality of patients with CS remains high despite the high utilization of mechanical circulatory support. Age, low body mass index, cardiac arrest at presentation, amount of vasopressor, and advanced organ failure requiring various support devices were poor prognostic factors for in-hospital mortality. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02985008.
