서울대학교 · Medicine
김기웅 교수의 연구실은 신경과학과 재료공학을 융합한 다학제적 연구를 수행하고 있습니다. 주요 연구 분야는 치매 및 인지저하의 유병률과 위험 인자 분석, 특히 노인층에서의 인지기능 저하를 조기에 진단하고 예방하기 위한 생체지표 탐색입니다. 동시에 고분자 재료의 합성 및 물성 향상 기술을 통해 의료용 생분해성 소재 개발에도 기여하고 있습니다. 이는 신경질환 진단과 치료를 위한 새로운 소재 기반 기술의 융합을 목표로 합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Minimally invasive surgery for spinal disorders is predicated on the following basic principles: (1) avoid muscle crush injury by self-retaining retractors; (2) do not disrupt tendon attachment sites of key muscles, particularly the origin of the multifidus muscle at the spinous process; (3) use known anatomic neurovascular and muscle compartment planes; and (4) minimize collateral soft-tissue injury by limiting the width of the surgical corridor. The traditional midline posterior approach for l
We investigated the prevalence of dementia and mild cognitive impairment (MCI) and the factors associate with risk of dementia from a representative nationwide sample of Korean elders. 8,199 randomly-sampled Koreans aged 65 years or older were invited to participate in the Phase I screening assessment using Mini-Mental State Examination by door-to-door home visit, and 6,141 subjects (response rate = 74.9%) responded. Among them, 2,336 subjects were invited to participate in the Phase II diagnost
As early markers of cognitive decline, long sleep latency can be used for elderlies with NC or MCI, whereas long sleep duration and relatively early sleep time might be used for cognitively normal elderlies only. Ann Neurol 2018;83:472-482.
To compare the diagnostic accuracies of the Revised Hasegawa Dementia Scale (HDS-R) and Mini-Mental Status Examination (MMSE) for Alzheimer's diseases (AD), we administered them simultaneously to 82 AD patients and 82 age- and sex-matched nondemented control subjects. The area under the receiver operator curve (AUC) for AD of the HDS-R (AUC(HDS-R)) and MMSE (AUC(MMSE)) were bigger than 0.90 indicating that both tests are useful for detecting AD. However, AUC(HDS-R) (0.952) was significantly larg
To prepare poly(lactic acid) (PLA) with improved mechanical properties, high-molecular-weight poly(L-lactic acid) (PLLA) was synthesized by the direct polycondensation of lactic acid in solution phase. During polymerization, the molecular weight of PLA was influenced by the water content present in the solution; thus, the experimental apparatus was designed to remove the water efficiently and this study was focused on the optimization of the polymerization conditions such as polymerization time,
The aim of this study was to determine the prevalence, neuropsychiatric comorbidities, iron metabolism and potential risk factors of restless legs syndrome (RLS) in the elderly Korean population. As a community-based epidemiological study, a simple random sample of 1118 was drawn from a roster of 61 730 adult individuals aged 65 years and older and 714 participated. The diagnosis of RLS was established in face-to-face interviews using the four minimal diagnostic criteria for RLS recommended by N
Parity is associated with women's risk of dementia, though this is not uniform across regions and dementia subtypes.
Our results suggest that the mortality risk of MCI in Asian countries may be comparable to that in Western countries, and MCI can contribute to the death of the elderly as much as dementia.
The measurement of gait parameters of elderly individuals with normal cognition using a TAA placed on the body's center of mass was reliable and showed superiority over the GAITRiteⓇ with regard to gait variability and asymmetry. The TAA system was a valid tool for measuring basic gait parameters. Considering its wearability and low price, the TAA system may be a promising alternative to the pressure sensor walkway system for measuring gait parameters.
