The University of Osaka · 의학
이 교수의 연구실은 레닌-안지오텐신 시스템(RAS)과 관련된 단백질, 특히 ACE2와 AT1 수용체의 기능 및 신호전달 메커니즘을 중심으로 심혈관계 질환, 고혈압, 노화와 관련된 혈전증 등 만성질환의 분자 기전을 규명하고 있습니다. 특히 ACE2의 보호적 기능과 oxLDL이 AT1 수용체를 통해 유도하는 비정상적 신호전달 경로의 역할을 다각도로 연구하고 있으며, 이는 심장 및 혈관 기능 저하의 예방 전략 개발에 기여하고자 합니다. 또한, 대사질환과 관련된 지방세포 기능 및 장내 염증 조절 메커니즘에 대해서도 관심을 기울이고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Angiotensin-converting enzyme 2 (ACE2) is a carboxypeptidase that cleaves angiotensin II to angiotensin 1-7. Recently, it was reported that mice lacking ACE2 (ACE2(-/y) mice) exhibited reduced cardiac contractility. Because mechanical pressure overload activates the cardiac renin-angiotensin system, we used ACE2(-/y) mice to analyze the role of ACE2 in the response to pressure overload. Twelve-week-old ACE2(-/y) mice and wild-type (WT) mice received transverse aortic constriction (TAC) or sham o
Our results suggest that adipocytes in hypertrophied mesenteric adipose tissue produce and secrete significant amounts of adiponectin, which could be involved in the regulation of intestinal inflammation associated with CD.
Thrombotic cardiovascular diseases increase in incidence in the elderly, a tendency dependent on the age-related changes in vascular and hemostatic systems that include platelets, coagulation, and fibrinolytic factors as well as in the endothelium. The hypercoagulability of and advanced sclerotic changes in the vascular wall may contribute to the increased incidence of thrombosis in the elderly. One of the important key genes for aging-associated thrombosis is plasminogen activator inhibitor-1 (
l.-Introduction.-Theproblem to determine the order $f(n)$ of the free distributive lattice $FD(n)$ generated by $n$ symbols $\gamma_{1},$ $\cdots,$ $\gamma_{n}$ was first proposed by Dedekind, but very little is known about this number [1, p. 146].Only the first six values of $f(n)$ are computed, and enumerations of further $f(n)$ appear to lie beyond the scope of any reasonable methods known today.It might, however, be pointed out that Morgan Ward, who found $f(6)$ by the help of computing mach
Angiotensin converting enzyme-2 (ACE2) is a multifunctional transmembrane protein recently recognised as the entry receptor of the virus causing COVID-19. In the renin-angiotensin system (RAS), ACE2 cleaves angiotensin II (Ang II) into angiotensin 1-7 (Ang 1-7), which is considered to exert cellular responses to counteract the activation of the RAS primarily through a receptor, Mas, in multiple organs including skeletal muscle. Previous studies have provided abundant evidence suggesting that Ang
The angiotensin II type 1 receptor (AT1) is a 7-transmembrane domain GPCR that when activated by its ligand angiotensin II, generates signaling events promoting vascular dysfunction and the development of cardiovascular disease. Here, we show that the single-transmembrane oxidized LDL (oxLDL) receptor (LOX-1) resides in proximity to AT1 on cell-surface membranes and that binding of oxLDL to LOX-1 can allosterically activate AT1-dependent signaling events. oxLDL-induced signaling events in human
