The University of Tokyo · 의학
Koki Nakanishi 교수의 연구실은 심혈관계 질환의 병태생리학적 기전을 규명하고, 특히 심장 구조와 기능, 대사 및 신장 기능 이상이 심혈관계에 미치는 영향을 중심으로 연구를 진행하고 있습니다. 특히 심방세동의 예측 인자로 작용하는 심내막지방조직(영역)의 부피, 혈관 기능 이상, 심장기계보조장치를 통한 심장기능 이상 등에 대한 정밀 영상 및 생리학적 분석이 핵심입니다. 또한 수면 중 혈압 및 심박수 변화가 뇌혈관 손상과 관련이 있음을 규명하며 뇌심혈관계 연관성 연구에도 기여하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
This is the first study demonstrating that peri-atrial EAT volume estimated by MDCT excellently predicted the development of new-onset AF in patients with CAD, independent of LA enlargement.
This TTDE study demonstrated that CFR was a significant and independent determinant of long-term cardiovascular events, ACS events and HF in patients with coronary artery disease. A CFR greater than 2.0 was not suitable to predict a favorable long-term outcome, even in the absence of obstructive coronary narrowing.
Significant residual TR was observed in ≈25% patients supported with LVAD over 1 year and was associated with unfavorable outcome.
Background:Chronic kidney disease (CKD) is strongly associated with coronary artery disease (CAD), although the underlying pathophysiological mechanism remains unclear. Epicardial adipose tissue (EAT) has recently been recognized as an important source of various pro-inflammatory cytokines causing coronary atherosclerosis. This study investigated the relationship between CKD and EAT volume in association with high-risk plaque.Methods and Results:The study included 275 patients with an estimated
Elevated night-time SBP is strongly associated with subclinical cerebrovascular disease. Night-time SBP by ABPM allows to identify individuals at higher risk of hypertensive brain injury.
In a predominantly elderly cohort, elevated nighttime HR was associated with WMHV, suggesting an independent role of HR in subclinical cerebrovascular disease.
Background Chronic kidney disease (CKD) is an independent risk factor for atrial fibrillation, although the pathophysiological mechanisms remain unclear. This study investigated the relationship between CKD and left atrial (LA) volume and function in a sample of the general population without overt cardiac disease. Design and methods We examined 358 participants from the Cardiovascular Abnormalities and Brain Lesions study. The LA minimum volume index (LAVI<sub>min</sub>), LA maximum volume inde
