Suk Kyoon An
연세대학교 정신과학교실 · 의학
Suk Kyoon An 교수의 연구실은 정신분열증의 발병 기전과 조기 간병을 위한 생물학적 기초를 규명하는 데 초점을 맞추고 있습니다. 주로 초고위험군(UHR) 및 최근 발병한 정신분열증 환자를 대상으로 신경생물학적 생체지표(예: OXTR 유전자 메틸화, 이벤트 관련 전위), 정서 인식 장애, 대처 전략 등을 연구하며, 정서 조절 및 사회성 장애의 유전적·에피제네틱적 기전을 탐구하고 있습니다. 특히 정신병 전 단계에서의 병리적 기전을 이해하고, 조기 간병 전략 수립에 기여하는 데 목적이 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
These results suggest that event-related potentials can be used as a neuronal correlate of alcohol craving in alcohol-dependent patients. Future investigations will be needed to assess the frequency of relapse in the patients included in this study, to elucidate the meaning of the observed results with regard to the therapeutic outcomes.
Negative symptoms are recognized as a fundamental feature of schizophrenia throughout the disease course. Epigenetic alterations in the oxytocin receptor gene (OXTR) may be a key mechanism involved in social-emotional disturbances of schizophrenia. Here, we investigated OXTR methylation and its association with clinical and brain network connectivity phenotypes of negative symptoms, particularly anhedonia-asociality, in individuals with recent-onset schizophrenia (ROS) and at ultrahigh risk (UHR
This study's aim was to investigate coping strategies and their relationship to symptoms in people at ultra high risk (UHR) for psychosis compared with recent-onset schizophrenia (SPR) and healthy controls. Thirty-three UHR participants, 22 SPR patients, and 33 healthy controls completed the Ways of Coping Questionnaire and other clinical measures. People at UHR for psychosis showed significantly more reliance on tension-reduction and less reliance on problem-focused coping than healthy controls
Our findings suggest that questionnaire-assessed basic symptoms, irrespective of their predictive validity, may predict a psychotic breakdown in pre-identified UHR individuals who are with genetic vulnerability to schizophrenia. Including all 3 psychosis-proneness dimensions into prediction models might help establish a more valid pathogenetic model of schizophrenia, and moreover, may provide some clues about course alteration strategies in hopes of preventing UHR individuals from converting to
UHR individuals exhibited inaccuracy and negative bias of facial emotion recognition. Furthermore, schizotypy scores were associated with inaccuracy but not with negative bias of facial emotion recognition. Paranoia level was correlated with "disgust" responses for neutral faces but not with inaccuracy. These findings suggest that inaccuracy and negative bias of facial emotion recognition reflect different underlying processes, and that inaccuracy may be a vulnerability marker for schizophrenia.
