东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Minoru Kitago's research lab specializes in translational oncology, focusing on the molecular mechanisms underlying cancer progression and immune evasion, particularly in gastrointestinal and skin malignancies. Key research directions include identifying genetic and epigenetic drivers of metastasis—such as RUNX3 downregulation and BRAF mutations in thyroid and melanoma cancers—evaluating tumor microenvironment interactions, and developing immunotherapeutic strategies like dendritic cell vaccination for pancreatic cancer. The lab also pioneers liquid biopsy techniques for circulating tumor cell (CTC) detection and characterization, integrating genomics and transcriptomics for precision oncology applications.
Professor Ryoichi Horisaki's research lab specializes in computational imaging and optical sensing, focusing on single-shot, high-speed, and model-free techniques for capturing complex optical fields. The lab develops advanced methods based on compressive sensing, phase retrieval, and machine learning to reconstruct multidimensional data—such as amplitude, phase, spectral, and polarimetric information—from minimal measurements. Key innovations include coded aperture imaging, randomized illumination, and generalized sampling frameworks that enable compact, efficient, and robust optical systems for applications in holography, biomedical imaging, and dynamic scene reconstruction.
Professor Shinsuke Yasuda's research lab focuses on the molecular and immunological mechanisms underlying autoimmune and thrombotic disorders, particularly systemic lupus erythematosus (SLE) and antiphiphospholipid syndrome (APS). The lab investigates genetic and post-translational modifications of key proteins such as RasGRP1 and beta(2)-glycoprotein I (beta(2)-GPI), exploring their roles in immune cell signaling and autoantibody development. Recent work also examines novel therapeutic targets, such as GLP-1 receptor agonists, for autoimmune myopathies. The lab integrates molecular biology, immunology, and translational research to identify biomarkers and develop innovative treatments for autoimmune and thrombotic diseases.
Professor Kansei Inamura's research lab specializes in the mathematical and physical foundations of topological phases of matter, with a focus on symmetry-protected topological phases, anyonic statistics, and non-invertible symmetries in low-dimensional quantum systems. The lab develops topological quantum field theories (TQFTs), commuting projector Hamiltonians, and lattice models—such as fusion surface models—that realize generalized symmetries, including fusion categories, 2-groups, and non-abelian anyons. A central theme is the construction of microscopic models and their connection to classical statistical models, along with the formulation of topological invariants and non-local order parameters using state-sum TQFTs and supercategory extensions. The lab also investigates fermionic and spin TQFTs, entanglement measures, and bulk-boundary correspondences in the context of non-invertible symmetries and SPT interfaces.
Professor Takeshi Hayashida's research lab specializes in the physics of emergent quantum materials, with a focus on novel ferroic orders such as ferroaxiality, chirality, and magnetoelectricity in complex oxides. The lab employs advanced optical techniques—particularly electrogyration and nonreciprocal optical effects—to experimentally probe and manipulate hidden order parameters that are otherwise difficult to access. A central theme is the development of new methods to visualize and control nanoscale domain structures in materials with broken symmetries, including antiferromagnets and chiral crystals.
Professor Takeshi Hasegawa's research lab specializes in advanced spectroscopic techniques and molecular-level materials science, focusing on the development of innovative infrared spectroscopy methods such as MAIRS and polarized vibrational spectroscopy for probing molecular orientation and interfacial phenomena in thin films. The lab investigates the fundamental physical chemistry of fluorinated materials, particularly perfluoroalkyl (Rf) compounds, using novel theoretical models like the stratified dipole-arrays (SDA) theory to explain their unique surface properties, including hydrophobicity despite high molecular dipole moments. Another key direction involves the engineering of high-temperature superconducting (HTS) cables using Bi-2212 round wires, emphasizing mechanical robustness and critical current performance under extreme conditions. The lab bridges experimental spectroscopy, theoretical modeling, and materials engineering to address long-standing challenges in surface science and functional materials.
Professor Koji Miki's research lab specializes in transition-metal-catalyzed carbene transfer reactions, focusing on the in situ generation of reactive carbene complexes from alkynes, alkenes, and ene-yne-ketones. The lab explores mechanistic pathways such as 6-endo-dig and 5-exo-dig cyclizations to form versatile carbenoid intermediates that enable efficient cyclopropanation and C–H functionalization. A key theme is the development of atom-economical, catalytic transformations using late transition metals like Ru, Rh, Pd, and Pt, as well as Cr-based systems. The lab also extends its methodology to bioactive molecule synthesis and functional nanomaterials, including targeted imaging agents for tumor detection.
Professor Shuji Kaneko's research lab focuses on the molecular and cellular mechanisms underlying neuronal and glial cell dysfunction in neurological disorders, with a particular emphasis on ion channels such as TRPM2 and TRPV4 in neurodegeneration and neuroinflammation. The lab investigates how oxidative stress and calcium signaling contribute to neuronal death and microglial activation, aiming to identify novel therapeutic targets for conditions like epilepsy and neurodegenerative diseases. Their work also explores the functional diversity of voltage-gated calcium channel isoforms and their roles in synaptic transmission and disease pathogenesis. Recent studies highlight the translational potential of targeting these channels to improve seizure control and reduce congenital malformations associated with antiepileptic drugs.
Professor Yu Sugihara's research lab specializes in plant genomics, functional genetics, and molecular plant pathology, with a focus on understanding the genetic and evolutionary mechanisms underlying disease resistance and crop domestication. The lab employs advanced sequencing technologies and bioinformatics pipelines—such as MutMap and QTL-seq—to identify key genes controlling agronomic traits in economically important crops, particularly yams and solanaceous species. A central theme of the lab’s work is dissecting the molecular mechanisms of nucleotide-binding domain and leucine-rich repeat (NLR) immune receptors, including their activation, oligomerization, and evasion by pathogenic effectors. The lab also investigates the complex evolutionary histories of polyploid and hybrid crop species, especially in the genus *Dioscorea*, to clarify their origins and domestication pathways.
Professor Mizuho Nishio's research lab specializes in medical image analysis and artificial intelligence applications in oncology, with a focus on improving diagnostic accuracy and efficiency in lung and abdominal cancers. The lab develops advanced deep learning models—particularly U-Net variants—combined with innovative data augmentation and generative techniques like GANs for automated organ and tumor segmentation in CT and MRI. Key research directions include radiomics, low-dose CT image reconstruction, and adaptive imaging protocols to reduce radiation exposure while maintaining diagnostic quality. The lab also emphasizes transfer learning and model generalization to enhance clinical applicability across diverse imaging datasets.
Professor Yusuke Katayama's research lab specializes in prehospital emergency medicine and trauma care, with a focus on improving outcomes for acute and critically ill patients through data-driven approaches and health information technology. The lab investigates prehospital factors affecting hospital acceptance, evaluates the impact of clinical protocols such as pelvic fracture management, and explores the role of timely imaging and digital tools—like smartphone-based information sharing—in enhancing emergency care. Their work is deeply rooted in real-world trauma registries and clinical data, aiming to optimize emergency medical systems and reduce mortality in acute conditions.
Professor Tsuyoshi Takahashi's research lab focuses on immunology and neurodevelopmental biology, with a central emphasis on innate-like T cells, particularly invariant natural killer T (iNKT) cells, and their roles in immune regulation and homeostasis. The lab investigates the development, function, and heterogeneity of human and mouse iNKT cells, including novel subsets such as CD8+ iNKT cells, and explores their potential in immunotherapy. Additionally, the lab contributes to understanding the mechanisms of neocortical neurogenesis, particularly the dynamics of neuronal production in the embryonic ventricular zone. These interdisciplinary studies bridge immunology and developmental neuroscience, aiming to uncover fundamental principles of cell fate decisions and immune system regulation.
Professor Takuro Saito's research lab focuses on surgical oncology and transplant surgery, with a strong emphasis on improving postoperative outcomes and quality of life in gastrointestinal cancer patients. The lab investigates inflammatory markers like CRP as prognostic indicators after gastric cancer surgery and explores innovative surgical techniques such as function-preserving gastrectomies and less invasive procedures for gastric tube cancer. Additionally, the lab contributes to advancing islet transplantation using donation after circulatory death (DCD) donors, particularly in regions with limited donor availability. Their work integrates advanced imaging techniques and long-term functional outcomes to optimize surgical strategies and patient recovery.
Professor Tomoaki Mameno's research lab specializes in oral implantology and biomaterials, focusing on the prevention, prediction, and risk factor analysis of peri-implant diseases. The lab employs advanced machine learning techniques to develop predictive models for peri-implantitis, integrating clinical, demographic, and biomechanical parameters. Research also explores the influence of occlusal factors, oral hygiene, and systemic health on implant longevity and patient outcomes.
Professor Yusuke Hirata's research lab focuses on the molecular mechanisms underlying cellular responses to metabolic and oxidative stress, with a particular emphasis on the roles of trans-fatty acids (TFAs), magnesium homeostasis, and redox signaling in disease pathogenesis. The lab investigates how TFAs, especially elaidic acid, induce DNA damage, inflammation, and cell death through activation of stress kinase pathways such as ASK1-p38, and explores the regulatory functions of proteins like CNNM family transporters and TRIM48 in maintaining cellular redox and ion homeostasis. Their work bridges structural biology, cell signaling, and pathophysiology to uncover novel mechanisms linking dietary factors and cellular stress responses to neurodegenerative and cardiovascular diseases.
Professor Liam Baird's research lab focuses on the KEAP1-NRF2 signaling pathway, a central regulator of cellular defense against oxidative and electrophilic stress. The lab investigates the molecular mechanisms underlying NRF2 activation and its role in both cytoprotection and cancer progression, particularly in lung, esophageal, and liver tumors with KEAP1-NRF2 mutations. Using advanced techniques such as quantitative FRET and synthetic lethal screening, the lab aims to identify NRF2-selective therapeutic strategies for cancers driven by aberrant NRF2 activation. Their work bridges fundamental redox biology with translational oncology, targeting an unmet clinical need for precision therapies in NRF2-hyperactive tumors.
Professor Kosuke Murate's research lab specializes in advanced terahertz (THz) science and technology, focusing on the development of high-power, narrow-linewidth, and widely tunable THz sources using injection-seeded terahertz parametric generators (is-TPG). The lab pioneers innovative spectroscopic and imaging techniques with ultra-high dynamic range, enabling nondestructive inspection and material identification through highly attenuating packaging materials. Key advancements include multiwavelength THz generation, pulse front shaping using digital micromirrors, and integration with machine learning for enhanced analytical accuracy.
Professor Kuniyoshi Toyoshima's research lab focuses on the interplay between mental health, cognitive function, and psychosocial functioning in community-dwelling adults. The lab investigates how subjective cognitive complaints, depressive symptoms, and anxiety-related factors influence work performance, quality of life, and functional disability. A central theme is the mediating role of cognitive complaints in linking psychological symptoms to real-world outcomes such as presenteeism and social functioning.
Professor Michihito Kono's research lab focuses on the metabolic reprogramming of T cells and its role in autoimmune diseases, particularly systemic lupus erythematosus (SLE) and lupus nephritis. The lab investigates how key metabolic pathways—such as glycolysis, glutaminolysis, and mitochondrial metabolism—regulate the differentiation and function of T helper subsets, especially Th17 cells, which are central to autoimmune pathology. Using pharmacological, genetic, and molecular approaches, the lab uncovers how metabolic enzymes and signaling molecules (e.g., CaMK4, Gls1, PDH, HIF-1α) control immune cell fate and contribute to disease progression. The ultimate goal is to identify metabolic targets for novel therapeutic strategies in autoimmune disorders.
Professor Nobuko Hanada's research lab specializes in materials chemistry and solid-state chemistry, with a primary focus on hydrogen storage materials and electrochemical hydrogen generation. The lab investigates metal hydrides, complex hydrides, and ammine-based systems to develop efficient, reversible, and safe materials for hydrogen storage and release. A key research direction involves enhancing the kinetics and thermodynamics of hydrogen sorption through nanostructuring, catalytic doping, and advanced characterization techniques such as XAS and XRD. The lab also explores liquid ammonia as a hydrogen carrier, employing electrochemical methods for high-purity hydrogen production at ambient conditions.
