东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Masaharu Nakamura's research lab specializes in the development of transition-metal-catalyzed cross-coupling reactions, with a strong focus on iron-catalyzed transformations that enable chemoselective and functional-group-tolerant coupling of alkyl halides with various organometallic reagents. The lab pioneers mild, efficient, and enantioselective methods for constructing challenging carbon–carbon and carbon–heteroatom bonds, including the synthesis of optically active fluorinated ketones and all-carbon quaternary centers. Their work emphasizes sustainable catalysis, using earth-abundant iron instead of precious metals, and explores novel reactivity patterns such as carbometalation and decarboxylative allylation.
Professor Shuling Hu's research lab specializes in the development and performance evaluation of high-performance, self-centering, and energy-dissipating structural systems for enhanced seismic resilience. The lab focuses on innovative lateral load-resisting systems such as hybrid self-centering braced frames, self-centering energy-absorbing dual rocking core (SEDRC) systems, and shape memory alloy-based components, with an emphasis on reducing residual drifts and improving post-earthquake recovery. Research integrates advanced seismic design methodologies, nonlinear dynamic analysis, and life-cycle cost assessment to optimize structural performance under mainshock–aftershock sequences and near-fault pulse-like ground motions.
Professor Amit Kumar Chatterjee's research lab specializes in nonequilibrium statistical mechanics, quantum thermodynamics, and stochastic processes in low-dimensional systems. The lab investigates emergent phenomena such as quantum Mpemba effect, negative differential mobility, and dynamical phase transitions in driven dissipative systems, with a focus on exact solutions and non-equilibrium steady states. Using analytical, numerical, and computational methods, the group explores complex many-body dynamics in open quantum and classical systems, including quantum dots, lattice gases, and spatially extended nonlinear chains.
Professor Taigo Kato's research lab specializes in cancer immunology and translational immunotherapy, focusing on the role of T cell responses in kidney and breast cancers. The lab investigates neoantigen-specific T cell immunity, immune checkpoint blockade, and the tumor microenvironment using advanced next-generation sequencing to decode T cell receptor repertoires and tumor heterogeneity. Key research directions include developing donor-derived T cell therapies, understanding cryoablation-induced systemic anti-tumor immunity, and exploring kinase signaling pathways (e.g., TOPK/MELK) that regulate cancer stemness and immune evasion. The lab also explores the immunomodulatory potential of mesenchymal stromal cells, particularly through TSG-6 secretion, for applications in transplantation and cancer immunotherapy.
Professor Hiroyasu Yamaguchi's research lab specializes in advanced materials science and plant biotechnology, focusing on the design of stimuli-responsive self-assembled materials through molecular recognition and the application of ion beams in mutation breeding. The lab explores photoresponsive systems, particularly using azobenzene and cyclodextrin interactions, to create tunable hydrogels and functional macroscopic materials. In parallel, the lab investigates the use of heavy ion beams for inducing targeted genetic mutations in ornamental and crop plants, aiming to develop novel cultivars with improved traits. Their interdisciplinary work bridges supramolecular chemistry, polymer science, and plant genetics to address challenges in materials innovation and sustainable agriculture.
Professor Masataka Koide's research lab specializes in theoretical high-energy and statistical field theory, with a focus on non-invertible symmetries, topological defects, and duality symmetries in lattice gauge theories. The lab investigates the role of Kramers-Wannier-Wegner (KWW) duality and 1-form center symmetries in four-dimensional $bZ_2$ lattice gauge theories, particularly at critical points, to understand boundary conditions, topological defect junctions, and renormalization group flows. A central theme is the construction and classification of non-invertible topological defects and their implications for quantum field theory and condensed matter systems.
Professor Qingbo S. Wang's research lab specializes in computational and systems genetics, focusing on the functional characterization of genetic variation in human disease. The lab integrates large-scale genomic data—such as whole exomes, whole genomes, and multi-omics profiles—from biobanks and disease cohorts to dissect the regulatory mechanisms of non-coding and multi-nucleotide variants. Key research directions include statistical fine-mapping of causal variants, identification of expression and protein quantitative trait loci (eQTLs/pQTLs), and understanding the genetic basis of complex traits and infectious diseases like COVID-19. The lab emphasizes the development and application of functionally informed computational methods to prioritize variants with biological and clinical relevance.
Professor James M. Lisy's research lab specializes in gas-phase cluster spectroscopy, focusing on the structural, dynamic, and energetic properties of small ionic and molecular clusters. Using advanced techniques such as vibrational predissociation spectroscopy, tandem mass spectrometry, and tunable infrared lasers, the lab investigates solvation effects, hydrogen bonding networks, and ion-molecule interactions in finite systems. Their work provides critical insights into fundamental processes like ion selectivity, solvation shell formation, and structural transitions, often serving as a benchmark for theoretical models. The lab's pioneering studies on systems like (HF)n, Li⁺(H₂O)ₙ, and valinomycin-K⁺ complexes have significantly advanced the understanding of molecular recognition and transport at the molecular level.
Professor Yoichi Kakuta's research lab focuses on the genetic and molecular mechanisms underlying inflammatory bowel diseases, particularly Crohn's disease and ulcerative colitis, with a strong emphasis on ethnic-specific genetic susceptibility and pharmacogenomics. The lab investigates gene-environment interactions, including the role of thiopurine metabolism, autophagy-related genes, and immune-regulatory pathways such as TNFSF15 in disease pathogenesis. A key focus is identifying genetic biomarkers for disease prognosis and treatment response, especially in East Asian populations, where conventional pharmacogenetic models like TPMT testing are less effective. The lab also explores adverse drug reactions, such as mesalamine allergy, integrating clinical and genetic data to improve personalized treatment strategies.
Professor Shinichiro Ogawa's research lab specializes in animal genetics and genomics, with a focus on improving production traits in livestock such as pigs and cattle. The lab conducts genetic parameter estimation, genomic prediction, and genotype imputation using high-density SNP markers and low-density imputation strategies to enhance breeding accuracy. Key research directions include understanding the genetic architecture of reproductive and carcass traits, evaluating the impact of imputation on genomic relationships and prediction accuracy, and applying advanced statistical models such as random regression and repeatability models. The lab also investigates linkage disequilibrium and QTL effects in Japanese cattle breeds to support marker-assisted selection and genomic evaluation.
Professor Yonatan Hutabarat's research lab specializes in wearable sensing and intelligent control systems, with a strong focus on gait analysis, prosthetic knee control, and industrial valve diagnostics. The lab develops advanced algorithms using inertial measurement units (IMUs) and machine learning techniques—such as reinforcement learning and finite state machines—for real-time gait event detection and quantitative assessment in ambulatory settings. A key research direction involves the integration of sensor fusion, dynamic modeling, and artificial intelligence to enhance mobility assistance devices and improve clinical and industrial control system performance. The lab also investigates torque estimation in human gait using both physics-based and data-driven models.
Professor Naoki Akai's research lab specializes in robust and reliable localization and mapping for autonomous vehicles and mobile robots, particularly in dynamic and challenging environments such as rural and mountainous roads. The lab focuses on integrating advanced sensor data—such as LiDAR point clouds, magnetic field fluctuations, and intensity information—into probabilistic frameworks to enhance localization accuracy and uncertainty estimation. Key research directions include developing novel localization algorithms using normal distribution transform (NDT), Gaussian processes for large-scale magnetic mapping, and deep learning techniques like CNNs for real-time reliability assessment of localization results. The lab also emphasizes safety-critical aspects of autonomous systems, such as fault detection, relocalization, and robustness against environmental changes.
Professor Naoyuki Matsuda's research lab focuses on the molecular and cellular mechanisms underlying sepsis and acute organ dysfunction, with particular emphasis on endothelial dysfunction, inflammatory signaling pathways, and apoptosis in critical illness. The lab investigates key mediators such as NF-κB, FADD, and G(sα) protein in septic organ failure, especially acute lung injury and myocardial depression. Innovative therapeutic strategies, including gene therapy using siRNA and NF-κB decoy oligonucleotides, are explored to modulate pathological responses in sepsis. The lab also examines hemodynamic regulation, particularly the role of sympathomimetic agents like ephedrine in managing hypotension in clinical settings such as obstetric anesthesia.
Professor Koichi Morisaki's research lab specializes in vascular surgery and endovascular interventions, with a strong focus on peripheral arterial disease, critical limb ischemia, and aneurysm management. The lab investigates preoperative risk factors, frailty assessment, and long-term outcomes following revascularization and aneurysm repair, particularly in elderly and high-risk patients. Key research directions include optimizing treatment strategies through validated frailty indices, evaluating survival predictors, and identifying factors associated with complications such as wound issues and endoleak persistence after endovascular aneurysm repair.
Professor Takayuki Watanabe's research lab specializes in the development and characterization of advanced ferroelectric thin films, with a focus on bismuth layer-structured ferroelectrics (BLSFs) such as Bi4Ti3O12 and its doped variants. The lab investigates epitaxial film growth, site engineering through A- and B-site doping, and the control of crystal orientation to enhance ferroelectric properties like remanent polarization and fatigue resistance. Their work combines metalorganic chemical vapor deposition (MOCVD) with advanced structural and electrical characterization to enable applications in lead-free, durable ferroelectric memories and novel optoelectronic devices.
Professor Hiroyuki Kawamoto's research lab specializes in electrostatics-based particle and droplet manipulation, focusing on electrostatic traveling wave systems for precise transport and handling of particles, droplets, and soft bodies. The lab investigates fundamental mechanisms of electrostatic forces—such as Coulomb, dielectrophoresis, and image forces—enabling applications in microfluidics, lunar surface operations, and cleanroom technologies. Key research directions include particle transport in vacuum and air, electrohydrodynamic deformation of liquids, and electrostatic cleaning of lunar dust from space suits.
Professor Tayfun E. Tezduyar's research lab, the Team for Advanced Flow Simulation and Modeling (T★AFSM), specializes in advanced computational fluid dynamics and fluid-structure interaction (FSI) methods. The lab focuses on developing and applying space-time finite element formulations—particularly the Deforming-Spatial-Domain/Stabilized Space-Time (DSD/SST) method—for simulating complex, unsteady flows with moving boundaries, interfaces, and dynamic interactions. Their work spans challenging applications such as parachute dynamics, arterial hemodynamics, and flows with moving mechanical components, often leveraging massively parallel computing for high-fidelity simulations. The lab emphasizes stabilization techniques, mesh moving strategies, and efficient iterative solvers to ensure accuracy, robustness, and scalability.
Professor Keisuke Kataoka's research lab focuses on the molecular mechanisms underlying hematological malignancies, particularly T-cell lymphomas and leukemia, with an emphasis on identifying driver genetic and epigenetic alterations. The lab integrates multi-omics approaches—such as whole-exome sequencing, gene expression profiling, and epigenomic analysis—to dissect the pathogenesis of diseases like peripheral T-cell lymphoma, adult T-cell leukemia/lymphoma, and virus-associated lymphomas. A key focus is understanding how oncogenic pathways, including those involving transcription factors like Evi1 and immune checkpoint regulators like PD-L1, contribute to tumorigenesis and therapeutic resistance. The lab also investigates the impact of microenvironmental stressors, such as iron overload, on outcomes in hematopoietic stem cell transplantation.
Professor Syoichi Tashiro's research lab specializes in regenerative medicine and neurorehabilitation for spinal cord injury (SCI), focusing on combinatorial therapies that merge neural stem/progenitor cell (NS/PC) transplantation with rehabilitative interventions such as treadmill training and NMES. The lab investigates how rehabilitation enhances neural plasticity and functional recovery, particularly in the chronic phase of SCI, where tissue environment becomes refractory to treatment. Key research directions include the molecular mechanisms underlying BDNF-mediated restoration of KCC2 expression, which contributes to reduced spasticity and allodynia, and the cortical reorganization associated with sensorimotor recovery. The lab also explores synergistic effects between regenerative medicine and advanced neurorehabilitation to overcome the limitations of single therapies in chronic SCI.
Professor Naoki Hosoe's research lab specializes in gastrointestinal endoscopy and mucosal immunology, focusing on advanced endoscopic technologies for the diagnosis and management of small intestinal and colonic diseases. The lab investigates the pathogenesis of small intestinal disorders such as chronic nonspecific multiple ulcers (CNSU) and explores the role of chemokines like CCL25/CCR9 in lymphocyte homing to intestinal mucosa. It also contributes to the development and evaluation of capsule endoscopy systems, including colon and esophageal capsule endoscopy, aiming to improve early detection of colorectal and esophageal diseases.
