东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Masanori Iwase's research lab focuses on lifestyle and metabolic factors influencing the progression and management of type 2 diabetes and its complications. The lab investigates the impact of sleep duration, smoking, physical activity, and dietary habits—such as green tea and coffee consumption—on glycemic control, insulin resistance, and cardiovascular risk. Using both clinical and animal model studies, particularly in OLETF rats, the lab explores early hemodynamic changes in pancreatic islets during the prediabetic phase, aiming to identify modifiable targets for early intervention.
Professor Yusaku Nakabeppu's research lab focuses on the molecular mechanisms of DNA damage and repair, particularly oxidative stress-induced genomic instability. The lab investigates the roles of key enzymes such as MTH1, OGG1, and MUTYH in preventing mutations and maintaining genomic integrity, with implications for aging, neurodegenerative diseases like Alzheimer’s and Parkinson’s, and cancer. A central theme is the interplay between oxidative DNA damage, cellular metabolism, and systemic physiological outcomes, including energy homeostasis and metabolic disorders. The lab integrates molecular biology, mouse models, and human postmortem tissue analyses to uncover disease mechanisms and potential therapeutic targets.
Professor Kaoruko Shimizu's research lab specializes in respiratory medicine, with a focus on chronic airway diseases such as asthma and COPD. The lab investigates the pathophysiology of airway inflammation and remodeling, particularly through novel therapeutic agents like DHMEQ, and explores advanced imaging techniques—including CT-based deep learning and non-invasive pulmonary vascular metrics—for improved diagnosis and prognosis. A key emphasis is placed on identifying biomarkers and imaging phenotypes that predict disease progression and treatment response.
Professor Shu-Ping Hui's research lab specializes in lipidomics and bioactive lipid research, focusing on the identification, characterization, and biological functions of novel endogenous lipids such as short-chain fatty acid esters of hydroxy fatty acids (SFAHFAs). The lab investigates the roles of these lipids in metabolic diseases, oxidative stress, and liver disorders like nonalcoholic steatohepatitis (NASH), with an emphasis on lipid oxidation, redox regulation, and the Keap1-Nrf2 antioxidant pathway. Advanced mass spectrometry and fluorescent imaging techniques are employed to study lipid droplets and their pathological modifications in cellular models. The lab also explores natural compounds, such as flazin, for their cytoprotective and antioxidant properties in human hepatocytes.
Professor Koichi Fukunaga's research lab focuses on the identification and characterization of endogenous lipid mediators that resolve acute inflammation, particularly in critical illnesses such as acute lung injury (ALI) and severe viral infections like COVID-19. The lab investigates bioactive lipid pathways—such as the metabolism of presqualene diphosphate to presqualene monophosphate—and their roles in regulating immune cell function and inflammation resolution. Using integrative approaches combining experimental disease models, lipidomics, and human genetic studies, the lab aims to uncover novel therapeutic targets for inflammatory and infectious diseases.
Professor Yasuaki Kabe's research lab focuses on molecular mechanisms underlying immune regulation, inflammation, and cancer progression, with a strong emphasis on redox signaling, transcriptional regulation, and extracellular vesicles in disease pathogenesis. The lab investigates key transcription factors such as NF-κB and NF-Y, coactivators like hMBF1, and novel signaling molecules such as ASC as noncanonical receptors for metabolites like short-chain fatty acids. A central theme is the role of extracellular vesicles and exosomes in liquid biopsies, particularly for early cancer diagnosis using advanced detection systems like ExoCounter and glycomic profiling. The lab integrates molecular biology, systems biology, and translational technologies to uncover biomarkers and therapeutic targets in pancreatic cancer and immune-mediated diseases.
Professor Makoto Suematsu's research lab specializes in gasotransmitter biology and redox signaling, focusing on the roles of gaseous signaling molecules such as carbon monoxide (CO), nitric oxide (NO), and hydrogen sulfide (H2S) in physiological and pathological processes. The lab investigates the molecular mechanisms of heme-based proteins in gas generation, sensing, and signaling, particularly in vascular and metabolic regulation. Using advanced analytical techniques like capillary electrophoresis-time-of-flight mass spectrometry and crystallography, the lab explores how these gaseous mediators influence cellular metabolism, liver function, and disease progression, including hepatotoxicity and cancer. Their work bridges systems biology, metabolomics, and structural biology to uncover novel regulatory pathways in health and disease.
Professor Junya Inoue's research lab specializes in computational materials science and metallurgy, focusing on the design and development of advanced multi-principal element alloys (MPEAs) and intermetallic compounds through machine learning and thermomechanical processing. The lab integrates machine learning models—particularly Generalized Regression Neural Networks (GRNN)—with experimental validation to predict and optimize mechanical properties such as microhardness and wear resistance. Research also extends to understanding deformation mechanisms in soft materials and interfacial fracture toughness in Fe-Zn intermetallic systems, combining experimental testing with numerical simulations. The overarching goal is to accelerate the discovery of high-performance structural materials with tailored properties for engineering applications.
Professor Ruicong Xu's research lab specializes in nuclear reactor safety, with a primary focus on the analysis and mitigation of Core Disruptive Accidents (CDAs) in Sodium-cooled Fast Reactors (SFRs). The lab investigates critical phenomena such as molten-pool sloshing, debris bed formation, and self-leveling behavior, aiming to enhance understanding of severe accident progression and coolability. Additionally, the lab explores innovative engineering solutions, including aerosol agglomeration and advanced spray systems, to improve safety during nuclear decommissioning and accident mitigation. Their work combines experimental studies with advanced modeling and subspace-based retrieval techniques for nuclear debris and material behavior.
Professor Miki Ando's research lab specializes in developing next-generation immunotherapies using induced pluripotent stem cell (iPSC) technology. The lab focuses on generating functionally rejuvenated, antigen-specific cytotoxic T lymphocytes (CTLs) for treating refractory cancers, particularly Epstein-Barr virus-associated lymphomas and cervical cancer. A key direction involves engineering allogeneic, 'off-the-shelf' T cells with dual antigen recognition and immune evasion capabilities to enhance persistence and efficacy while minimizing rejection. The lab also explores novel strategies such as L-asparaginase-based therapies for natural killer/T-cell lymphomas and uses single-cell RNA sequencing to dissect T cell functionality and exhaustion.
Professor Naonori Hu's research lab specializes in the development and optimization of accelerator-based boron neutron capture therapy (BNCT) systems for clinical oncology. The lab focuses on neutron source design, beam shaping, and treatment planning to enhance the precision and safety of BNCT for deep-seated and superficial tumors. Key research directions include neutron filtration, dose distribution modulation, and micro- and macro-dosimetric characterization using advanced simulation and experimental validation.
Professor Takeshi Abe's research lab specializes in solid-state ionics and electrochemical interfaces, focusing on lithium-ion transport mechanisms at electrode/electrolyte boundaries. The lab investigates interfacial charge transfer resistances and activation energies in complex systems involving ceramic, polymer, and liquid electrolytes, with an emphasis on understanding the role of solvent-solute interactions and interfacial energetics. Their work combines ac impedance spectroscopy with theoretical calculations to design high-performance solid-state batteries and ion-conductive materials. The research aims to optimize interfacial stability and ionic conductivity for next-generation energy storage devices.
Professor Shuichi Suzuki's research lab specializes in the design and characterization of organic and organometallic materials with unique electronic and magnetic properties. Key research directions include the synthesis and spectroscopic investigation of stable organic radicals, diradicals, and charge-separated states in molecular systems, with a focus on spin-coupling phenomena, electron transfer processes, and long-lived charge-separated states. The lab employs advanced analytical techniques such as EPR, NMR, MS, and UV/Vis spectroscopy to probe electronic structures and dynamics in solution and solid states, particularly in systems with extended π-conjugation and tailored symmetry. Their work contributes significantly to the development of functional materials for molecular electronics, artificial photosynthesis, and spintronics.
Professor Shunichiro Nakao's research lab specializes in prehospital emergency medicine and trauma care, with a focus on improving outcomes for acute injury patients in Japan. The lab investigates prehospital care systems, airway management in trauma, non-operative management of solid organ injuries, and road traffic injury prevention across different age groups. Their work emphasizes evidence-based strategies to reduce mortality and improve trauma care delivery through large-scale registries and multicenter studies.
Professor Atsunari Kawashima's research lab specializes in translational oncology, focusing on the tumor immune microenvironment and predictive biomarkers in urological cancers, particularly renal cell carcinoma (RCC) and muscle-invasive bladder cancer (MIBC). The lab investigates T cell exhaustion, regulatory T cell dynamics, and systemic inflammatory markers to identify novel prognostic and predictive factors for treatment response and survival. Their work integrates molecular profiling, including RNA sequencing and gene set enrichment analysis, with clinical outcomes to guide personalized therapy strategies.
Professor Yumi Mitsuyama's research lab focuses on the intersection of neurodegenerative diseases, immunology, and critical care medicine. The lab investigates the pathological mechanisms underlying presenile dementia with motor neuron disease, cerebrovascular disease in aging populations, and immune dysregulation in severe infections such as COVID-19 and acute respiratory distress syndrome (ARDS). A key focus is on immune cell profiling using advanced single-cell technologies to understand long-term immune alterations and their implications for prognosis and immunotherapy. The lab also explores biomarkers such as splenic volume and metabolic parameters in predicting outcomes in critical illness.
Professor Yoshinori Yamaguchi's research lab specializes in microfluidic systems and analytical chemistry, with a focus on developing portable, integrated diagnostic devices for rapid and accurate pathogen detection. The lab pioneers innovative continuous flow PCR (CF-PCR) microfluidic chips that combine DNA amplification with on-chip electrophoresis, enabling point-of-care diagnostics with minimal sample handling and reduced risk of contamination. Key research directions include the design of all-in-one microfluidic biochips, optimization of multiplex PCR for periodontal pathogens, and the development of novel emulsion polymerization techniques for magnetic nanocomposite materials. The lab also explores advanced analytical methods such as in-capillary denaturing electrophoresis for RNA analysis using strong, biocompatible denaturants.
Professor Masaru Ito's research lab focuses on the molecular mechanisms underlying meiotic chromosome dynamics and DNA double-strand break (DSB) formation in gametogenesis. The lab investigates how higher-order chromosome architecture, including axis-loop structures and synaptonemal complexes, regulates meiotic recombination and crossover formation. Using advanced genomics and mouse genetics, the lab explores the roles of key proteins such as Rec8, FIGNL1, and pro-crossover RING-domain proteins (e.g., RNF212, HEI10) in ensuring accurate homologous recombination and chromosome segregation. The lab also develops innovative single-cell cloning techniques to study cell lineage and chromosomal behavior in early development and gametogenesis.
Professor Wataru Mizukami's research lab specializes in advanced quantum chemistry and computational materials science, focusing on strongly correlated electron systems and electronic structure theory. The lab develops cutting-edge ab initio methods—particularly multi-reference approaches like DMRG and coupled-cluster theories—to study complex quantum phenomena in low-dimensional materials, organic semiconductors, and magnetic molecules. Key research directions include the electronic structure of graphene nanoribbons, spin-state energetics in carbenes, and accurate potential energy surface construction for molecular dynamics and spectroscopy. The lab also pioneers quantum algorithms for quantum computing applications in quantum chemistry and molecular optimization.
Professor Hideaki Yamamoto's research lab focuses on the intersection of neuroscience, immunology, and drug delivery systems. The lab investigates the dynamic organization of neuronal networks using microfabricated in vitro models to understand brain network functionality and plasticity. It also explores cellular and molecular mechanisms in asthma, particularly eosinophil trafficking and endothelial adhesion molecule regulation, and examines lipoprotein-mediated drug transport as a novel therapeutic delivery strategy. These diverse research directions are united by a common theme of understanding and manipulating biological transport and cellular communication at the micro- and nanoscale.
