东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Akifumi Yogo's research lab specializes in laser-driven ion acceleration and its applications in radiobiology and neutron generation. The lab focuses on developing high-intensity laser-plasma interactions to produce quasimonoenergetic proton beams with ultra-short pulse durations, enabling precise irradiation studies on biological cells. Key research directions include understanding the underlying plasma physics of proton acceleration, optimizing laser parameters for enhanced efficiency, and exploring the radiobiological effects of laser-driven ions for cancer therapy. The lab also investigates laser-driven neutron sources, aiming to establish scalable and compact neutron generation systems.
Professor Hiroe Seto's research lab specializes in health data science and machine learning applications for preventive medicine, with a focus on developing and validating reliable risk prediction models for chronic diseases such as diabetes and metabolic syndrome. The lab emphasizes rigorous calibration assessment in predictive modeling, particularly through innovative methods like the variable-based probabilistic calibration plot (VPC-Plot) to improve model reliability for clinically important variables. Their work leverages large-scale population health data, such as the Kokuho-database in Osaka, Japan, to explore seasonal and demographic variations in metabolic health markers. The lab is at the forefront of advancing statistical methodology in machine learning for public health, ensuring models are not only accurate but also clinically trustworthy.
Professor Anindityo Patmonoaji's research lab specializes in pore-scale hydrodynamics and multiphase flow in porous media, with a focus on fluid displacement, dissolution, evaporation, and mineral precipitation processes. The lab employs advanced imaging techniques such as X-ray microcomputed tomography and microfluidic micromodels to visualize and quantify interfacial dynamics, capillary pressure, and mass transfer mechanisms. Key research directions include CO₂ dissolution in geological storage, salt precipitation during brine evaporation, and the stability of miscible and immiscible fronts under viscous and gravitational contrasts.
Professor Asuka Fujii's research lab specializes in the molecular-level characterization of hydrogen-bonded water networks and protonated water clusters using advanced vibrational spectroscopy techniques in the gas phase. The lab investigates the size-dependent structural evolution of these systems—from small clusters to nanoscale architectures—focusing on the emergence of bulk-like behavior and the coexistence of different proton hydration motifs such as Eigen and Zundel cations. By combining size-selected infrared spectroscopy with mass spectrometry and theoretical analysis, the lab uncovers fundamental principles of water structure, dynamics, and reactivity under extreme conditions, including ionization and radiation exposure. Their work bridges the gap between isolated molecular clusters and bulk water, offering insights relevant to atmospheric chemistry, radiation chemistry, and proton transport in biological systems.
Professor Takuya Hasegawa's research lab specializes in advanced functional materials, with a primary focus on luminescent phosphors for solid-state lighting and energy-efficient lighting technologies. The lab investigates novel garnet-structured and rare-earth-doped phosphors, emphasizing high quantum efficiency, tunable emission colors, and precise control of activator ion valence states. Additionally, the lab contributes to energy-saving technologies through research on high-efficiency combustion systems and thermal processes for industrial applications. Their work also extends to environmental science, analyzing ocean heat content anomalies and their links to climate phenomena such as ENSO.
Professor Naoto Kuroda's research lab specializes in translational neuropathology and urological oncology, focusing on identifying electrophysiological biomarkers for epilepsy surgery and elucidating the cellular microenvironment in rare and complex neoplasms. The lab investigates high-frequency oscillations and phase-amplitude coupling in epileptic brain tissue to improve surgical outcomes, while also exploring the immunohistochemical and morphological features of rare carcinomas such as signet-ring cell prostate cancer and micropapillary bladder cancer. A key focus is the characterization of stromal cell populations—including CD34-positive cells and myofibroblasts—in both normal and pathological tissues across the nervous system and gastrointestinal and urological organs. The lab integrates advanced immunohistochemistry and electrophysiological analysis to uncover novel diagnostic and prognostic markers in neurological and oncological diseases.
Professor Yuanyuan Guo's research lab specializes in the development of flexible, miniaturized, and biocompatible bioelectronic devices for neural interfacing and biomedical sensing. The lab focuses on integrating advanced materials—such as carbon nanotubes, shape-memory alloys, and polymer-based composites—into fiber-optic and microelectrode platforms for high-resolution, label-free electrophysiological and chemical sensing. Key research directions include implantable sensors based on light-addressable potentiometric sensors (LAPS), thermally-drawn fiber-based bioelectronics, and next-generation brain-machine interfaces with enhanced spatial resolution and long-term stability.
Professor Keiko Nakayama's research lab focuses on the molecular mechanisms regulating cell survival, apoptosis, and cell cycle control during development and disease. Her work centers on the roles of key regulatory genes such as Bcl-2 family members and cyclin-dependent kinase inhibitors (CKIs), particularly in hematopoietic system development and tumorigenesis. The lab investigates how precise control of apoptosis and cell cycle progression contributes to normal physiology and how their disruption leads to developmental defects or cancer. Using genetically engineered mouse models, the lab explores the functional specificity of these regulators in lymphocyte homeostasis and tissue maintenance.
Professor Kenichi Funamoto's research lab specializes in developing advanced microfluidic platforms to investigate the complex biological behaviors of cells under physiologically relevant conditions, particularly focusing on hypoxia and hemodynamic forces in tumor microenvironments. The lab integrates microfluidic devices with real-time imaging, ultrasonic measurement, and computational feedback to simulate and analyze blood flow and cellular responses with high precision. A central theme is understanding how oxygen tension gradients and endothelial barrier function influence cancer progression, metastasis, and drug delivery. The lab also pioneers innovative simulation techniques, such as Ultrasonic-Measurement-Integrated (UMI) simulation, to improve the accuracy of hemodynamic field reproduction in biomedical modeling.
Professor Azusa Kamikouchi's research lab specializes in the neurobiology of sensory systems, with a primary focus on auditory and mechanosensory processing in insects, particularly *Drosophila melanogaster* and the honeybee *Apis mellifera*. The lab investigates the functional organization of neural circuits underlying sound communication, gravity sensing, and olfactory discrimination, integrating molecular genetics, single-cell labeling, and imaging techniques. A central theme is understanding how distinct sensory modalities are encoded and processed in the insect brain at the cellular and circuit levels. The lab also explores molecular mechanisms of neural plasticity and signal transduction, especially involving calcium signaling and second messengers in higher brain centers such as the mushroom bodies and antennal mechanosensory and motor center.
Professor Kazuyuki Shimada's research lab focuses on the molecular pathogenesis and clinical management of rare and aggressive B-cell lymphomas, particularly intravascular large B-cell lymphoma (IVLBCL) and primary effusion lymphoma (PEL). The lab employs advanced genomic technologies such as whole-exome sequencing using cell-free DNA and patient-derived xenograft models to uncover the genetic drivers of these malignancies. A key research direction involves understanding the mechanisms of central nervous system involvement and treatment resistance in IVLBCL, especially in the context of rituximab-based therapies. The lab also investigates the tumor microenvironment and receptor biology, including angiotensin II signaling in immune cells, to identify novel therapeutic targets.
Professor Takashi Hibino's research lab specializes in advanced materials and electrochemical systems for intermediate- and low-temperature solid oxide fuel cells (SOFCs), with a strong focus on ceria-based electrolytes and noble metal-catalyzed anodes. The lab investigates ion transport mechanisms, electrocatalytic oxidation of hydrocarbons, and strategies to enhance cell performance while minimizing degradation from steam and carbon formation. Key research directions include developing efficient, durable, and cost-effective SOFCs using doped ceria, palladium, and ruthenium catalysts for clean energy conversion at reduced temperatures.
Professor Masashi Kato's research lab focuses on the molecular mechanisms underlying skin cancer development, particularly melanoma, with an emphasis on the roles of key signaling pathways such as RAS/RAF/MEK/ERK and PI3K/PTEN/AKT, as well as transcriptional regulators like MITF. The lab investigates environmental triggers—especially ultraviolet radiation—and their interplay with genetic and epigenetic alterations in melanocyte transformation. Additionally, the lab explores the toxicological impacts of environmental contaminants in drinking water, such as barium and arsenic, and their biological effects in human populations. The integration of molecular oncology, environmental health, and advanced imaging techniques underpins the lab’s multidisciplinary approach to understanding disease pathogenesis and identifying novel therapeutic targets.
Professor Hisashi Shimakoshi's research lab specializes in the development of bio-inspired and hybrid photocatalytic systems for environmental remediation and sustainable molecular transformations. The lab focuses on designing cobalamin (vitamin B12)-based catalysts and their integration with semiconductors like TiO2 or transition metal complexes to enable efficient dechlorination of persistent organic pollutants under mild conditions, including visible or UV light irradiation. Key research directions include the mechanistic study of C–X bond cleavage, the stabilization of reactive intermediates such as cobalt–carbon bonds, and the application of these systems in selective esterification and dehalogenation reactions. The lab also explores electrochemical and photoelectrochemical processes for the transformation of toxic halogenated compounds, emphasizing catalyst recovery and reusability.
Professor Seiji Ogo's research lab specializes in bioinspired inorganic chemistry, focusing on the design and synthesis of transition metal complexes that mimic the active sites of hydrogenase enzymes. The lab develops water-soluble organometallic catalysts for selective and efficient hydrogen transfer reactions, particularly in aqueous media under ambient conditions. Key research directions include the activation of H₂, the formation and reactivity of metal hydride species, and pH-dependent catalysis for sustainable transformations such as CO₂ reduction and reductive amination. The lab employs advanced structural techniques—such as neutron diffraction, X-ray crystallography, and NMR—to elucidate reaction mechanisms at the molecular level.
Professor Ryo Akasaka's research lab specializes in the development and optimization of highly accurate equations of state for refrigerants and fluid systems, with a focus on thermodynamic properties such as vapor pressure, density, sound speed, and phase equilibrium. The lab employs advanced Helmholtz energy-based equations of state, leveraging modern nonlinear fitting techniques and experimental data to achieve low uncertainties across wide temperature and pressure ranges. Their work supports the design and safety assessment of next-generation refrigerants used in cooling and heating applications.
Professor Toshihiro Shimada's research lab specializes in the epitaxial growth and electronic characterization of two-dimensional materials and organic semiconductors on atomically controlled substrates. The lab focuses on understanding interfacial electronic structures, work functions, and charge transfer phenomena at heterojunctions involving transition metal dichalcogenides, graphene-like materials, and organic semiconductors. Key techniques include photoemission spectroscopy, reflection high-energy electron diffraction (RHEED), and molecular beam epitaxy on vicinal and hydrogen-terminated silicon surfaces to achieve precise control over film morphology and crystallinity. The research aims to bridge fundamental surface science with applications in next-generation nanoelectronics and optoelectronic devices.
Professor Akihiko Ishida's research lab specializes in the development of innovative analytical methods and synthetic methodologies for environmental and biomedical applications. The lab focuses on creating miniaturized, portable sensing devices—particularly electrochemical and microfluidic platforms—for the sensitive detection of harmful substances such as mycotoxins (e.g., ochratoxin A) and environmental pollutants. Key research directions include the design of aptamer-based sensors, colorimetric detection using μPADs with advanced image analysis, and the synthesis of biologically relevant compounds using transition metal-catalyzed transformations and selective organic reactions. The lab emphasizes practical, field-deployable technologies with high sensitivity and selectivity.
Professor Tetsuya Sakai's research lab specializes in information retrieval (IR) evaluation and metric design, with a strong focus on statistical robustness, relevance assessment, and system evaluation under incomplete data conditions. The lab investigates the properties and reliability of IR effectiveness metrics—such as bpref, nDCG, and Q-measure—especially in scenarios involving graded relevance, query ambiguity, and limited human judgments. A key research direction involves improving evaluation practices through effect size reporting, confidence intervals, and bootstrap-based hypothesis testing to support more reliable and informative comparisons of IR systems. The lab also explores innovative indexing strategies, including the use of generic summaries for retrieval, particularly in the context of pseudo-relevance feedback and precision-oriented search.
Professor Shinji Tsujikawa's research lab specializes in theoretical cosmology, focusing on modified gravity theories and dark energy models that reconcile cosmic acceleration with local gravity constraints. The lab investigates $f(R)$ gravity, scalar-tensor theories, and string-inspired higher-order corrections to Einstein's gravity, aiming to construct viable cosmological models that pass both observational and phenomenological tests. Key research directions include the dynamics of matter density perturbations, the chameleon mechanism for screening local gravity effects, and the cosmological fate of the universe in various quantum-corrected gravity frameworks. The lab also explores bouncing and nonsingular cosmologies arising from quantum and string loop corrections, particularly in the context of pre-big-bang and ekpyrotic scenarios.
