东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Yasuyuki Goto's research lab focuses on parasitic diseases, particularly leishmaniasis and Chagas' disease, with an emphasis on identifying protective antigens and understanding host-parasite interactions. The lab employs bioinformatic and immunological approaches to discover tandem repeat (TR) domain-containing proteins as potential vaccine candidates and serodiagnostic markers. They also investigate host genetic factors, such as SNPs in human genes like PTPN11 (SHP-2) and EGF, that influence susceptibility to gastric atrophy and cancer in the context of chronic infections like *H. pylori*. The lab integrates parasitology, immunology, and molecular genetics to develop novel diagnostics and vaccines for neglected tropical diseases and infection-associated cancers.
Professor Takayuki Iriyama's research lab focuses on the molecular mechanisms underlying preeclampsia and cardiovascular complications in pregnancy, with a particular emphasis on placental signaling pathways involving hypoxia-inducible factor-1α (HIF-1α) and adenosine. The lab investigates how chronic activation of these pathways contributes to disease pathogenesis, especially in the context of angiotensin receptor autoimmunity and vascular dysfunction. They also explore maternal-fetal cardiovascular risks, including aortic dissection in Marfan syndrome and arrhythmogenic right ventricular cardiomyopathy during pregnancy, aiming to identify novel therapeutic targets and improve clinical management. Their work integrates preclinical models, molecular biology, and clinical observation to advance understanding of pregnancy-associated cardiovascular disorders.
Professor Satoshi Sasaki's research lab focuses on nutritional epidemiology and dietary assessment, with a strong emphasis on the role of dietary patterns and specific nutrients in chronic disease prevention, particularly cardiovascular diseases and cancer. The lab develops and validates food frequency and diet history questionnaires (e.g., DHQ, BDHQ) to improve dietary intake estimation in population studies. Research also extends to the impact of diet on metabolic and endocrine health, including sleep quality, thyroid function, and hormonal regulation, with a particular interest in sodium, fatty acids, and micronutrient intake in free-living populations. The lab integrates dietary assessment with biomarker validation to strengthen the reliability of nutritional data in epidemiological research.
Professor Shintaro Nakagawa's research lab specializes in polymer science and materials engineering, focusing on the design and characterization of advanced functional polymers with precise nano- and microstructures. Key research directions include the controlled synthesis of star-shaped polymer networks for high-performance elastomers, the confinement effects on polymer crystallization in nanostructured environments, and the development of stimuli-responsive hydrogels with tunable phase behavior. The lab employs advanced analytical techniques such as SANS, WAXD, DSC, and MRI to probe the structure-property relationships in soft materials at the nanoscale.
Professor Shuchuang Dong's research lab specializes in fluid-structure interactions in marine aquaculture systems, with a focus on flexible net cages, closed containment fish farming, and hydrodynamic performance. The lab investigates drag forces, cage deformation, flow dynamics, and fish behavior within net cages using numerical simulations, laboratory experiments, and physical modeling. Key research directions include optimizing cage design for environmental resilience, improving fish welfare in closed systems, and developing innovative harvesting technologies. The lab also explores the influence of fish school behavior on internal flow fields and cage performance, contributing to sustainable aquaculture solutions.
Professor Kosei Nagata's research lab focuses on the molecular mechanisms underlying inflammatory responses and musculoskeletal diseases, with a particular emphasis on platelet-leukocyte interactions in inflammation and the role of transcription factors such as Runx2 and Runx3 in cartilage homeostasis and osteoarthritis. The lab investigates how glycocalyx components on leukocytes modulate oxidative burst responses during immune cell activation, and also explores clinical outcomes in orthopedic surgery, especially the impact of comorbidities like diabetes on postoperative recovery. Their work bridges basic immunology and translational orthopedic research, aiming to identify novel therapeutic targets for inflammatory joint diseases and improved surgical outcomes.
Professor T. Hassan's research lab specializes in high-energy astrophysics and multi-messenger astronomy, focusing on the study of high-energy phenomena in the universe through gamma-ray and radio observations. Key research directions include the measurement of the extragalactic background light using very high-energy gamma-ray data from telescopes like MAGIC and Fermi-LAT, the investigation of fast radio bursts and their multi-wavelength counterparts, and the application of machine learning to classify active galactic nuclei based on gamma-ray properties. The lab also conducts detailed variability studies of blazars, combining data across the electromagnetic spectrum to understand particle acceleration and emission mechanisms in relativistic jets.
Professor Kentaro Ifuku's research lab specializes in the molecular mechanisms of photosynthetic electron transport and the structural-functional organization of photosystems, particularly Photosystem II and the chloroplast NADH dehydrogenase-like (NDH) complex. The lab investigates the roles of extrinsic proteins in the oxygen-evolving complex (OEC), focusing on their evolutionary diversification, metal ion regulation, and stabilization of the Mn4CaO5 cluster. Using biochemical, biophysical, and spectroscopic approaches—including cross-linking, FTIR difference spectroscopy, and subunit reconstitution—his team elucidates the dynamic interactions and topological features of these critical photosynthetic components. The lab also explores functional specialization within the OEC protein family, including connections to cyclic electron transport via the NDH complex in higher plants and algae.
Professor Sotaro Katayama's research lab specializes in advanced optimal control methodologies for robotic systems, with a strong focus on model predictive control (MPC) for legged and humanoid robots. The lab develops efficient numerical algorithms—particularly based on inverse dynamics, multiple shooting, and the continuation/GMRES (C/GMRES) method—to enable real-time, high-fidelity control of complex dynamical systems with rigid contacts and state-dependent switching. A key innovation is the integration of online switching time optimization and automatic code generation tools (e.g., AutoGenU for Jupyter) to streamline NMPC implementation and simulation. The lab’s work bridges theoretical optimal control with practical robotics applications, emphasizing computational efficiency and real-time performance.
Professor Satoru Seo's research lab specializes in advancing image-guided surgical oncology, with a focus on improving the precision and outcomes of liver surgery. The lab develops innovative intraoperative imaging technologies, such as the Multi-Modality Imaging Navigation System (MIPS), to enhance real-time surgical guidance and anatomical localization during liver resection. By integrating molecular imaging with clinical outcomes, the lab investigates biomarkers like FDG-PET uptake and P-glycoprotein expression to predict tumor behavior and patient prognosis in hepatocellular carcinoma. Their work bridges medical imaging, surgical oncology, and molecular diagnostics to optimize personalized treatment strategies.
Professor Qian Niu's research lab focuses on public health informatics, digital health, and the intersection of artificial intelligence with societal challenges. The lab investigates public sentiment and behavioral responses to health crises—particularly during the COVID-19 pandemic—using social media data and natural language processing. Key research directions include vaccine hesitancy, digital health system optimization, and the application of large language models to model human cognition and public health decision-making. The lab also explores how information dissemination and digital transformation impact public health outcomes in Japan and beyond.
Professor Seiji Yamazoe's research lab specializes in the atomic-level design and characterization of nanoscale gold and transition metal clusters, focusing on their electronic structure, bonding hierarchy, and catalytic properties. The lab employs advanced X-ray spectroscopic techniques—such as XAFS and XANES—combined with density functional theory (DFT) calculations to understand how cluster size, composition, and interface structures govern reactivity in oxidation and photocatalytic reactions. Key research directions include the precise synthesis and doping of thiolate-protected gold clusters, the role of ligand fields in transition metal oxides, and the development of efficient, selective catalysts for environmental and energy applications such as CO oxidation and ammonia selective catalytic oxidation (photo-SCO).
Professor Hideki Kanemoto's research lab focuses on the intersection of neurology, dementia spectrum disorders, and biomedical signal processing. The lab investigates the neurocognitive and neuroimaging correlates of dementia with Lewy bodies (DLB), particularly the prodromal manifestations such as visual and auditory hallucinations, psychomotor slowing, and regional brain perfusion deficits. It also explores behavioral and psychological symptoms of dementia (BPSD) and their impact on caregiver burden, while contributing to the statistical modeling of electromagnetic interference in digital radio systems for robust communication in noisy environments. The lab integrates clinical neuroscience with engineering approaches to understand and improve outcomes in neurodegenerative diseases and signal integrity in real-world interference conditions.
Professor Naoki Hosen's research lab focuses on identifying and targeting cancer stem cells, particularly in hematological malignancies and solid tumors, with an emphasis on leukemic and glioblastoma stem cells. The lab investigates tumor-associated antigens such as CD96, WT1, and CD48 as potential therapeutic targets for immunotherapy and monoclonal antibody-based treatments. Key research directions include the identification of surface markers for cancer stem cell isolation, the development of peptide vaccine and antibody therapies, and the functional characterization of molecules like ALCAM and Bmi-1 in tumor initiation and self-renewal. The lab integrates molecular biology, flow cytometry, and preclinical models to advance novel immunotherapeutic strategies for cancer treatment.
Professor Yutaro Motoori's research lab specializes in computational fluid dynamics and turbulence physics, focusing on the multiscale coherent structures and particle-laden flows in high-Reynolds-number turbulent boundary layers and channel flows. The lab employs direct numerical simulations to investigate the generation mechanisms of hierarchical vortices, the role of particle wakes in turbulence modulation, and the inhomogeneous distribution of inertial particles in wall turbulence. A central theme is the application of coarse-graining techniques to extract and analyze multiscale vortical structures and their dynamical interactions with particles and flow fields.
Professor Shigetada Kawabata's research lab focuses on the molecular pathogenesis of Group A Streptococcus (GAS), particularly the mechanisms underlying bacterial immune evasion, tissue invasion, and host-pathogen interactions. The lab investigates key virulence factors such as fibronectin-binding proteins, SpeB protease, and complement degradation systems that enable GAS to subvert innate immunity and disseminate in host tissues. Their work also explores host responses to infection and the potential of surface proteins as vaccine candidates, contributing to the development of novel therapeutics and preventive strategies against invasive streptococcal diseases.
Professor Li Yi's research lab specializes in advanced terahertz and microwave imaging technologies, with a strong focus on photonic radar systems, high-resolution sensing, and innovative signal processing for subsurface and 3D imaging. The lab develops compact, high-performance THz transceivers and frequency-modulated continuous-wave (FMCW) photonic radar systems to achieve submillimeter range resolution and robust imaging in challenging environments. Key research directions include inverse problems in electrical capacitance tomography (ECT), iterative data reconstruction for ground-penetrating radar (GPR), and velocity analysis using ℓ-1 regularization for precise shallow subsurface inspection. The lab integrates photonics, signal processing, and inverse imaging techniques to enable practical, high-accuracy sensing solutions in security, civil engineering, and non-destructive testing.
Professor Tomoaki Nishino's research lab specializes in molecular-scale electron transport and nanoscale characterization using advanced scanning probe microscopy techniques. The lab focuses on understanding and controlling electron transfer at single-molecule junctions through noncovalent interactions such as hydrogen bonding, metal coordination, and charge-transfer interactions. By developing functional molecular tips—such as carboxylated carbon nanotubes, fullerenes, and metal-coordinated molecules—the lab enables high-resolution, selective imaging and quantitative measurement of electronic properties at the single-molecule level. Their work provides fundamental insights into molecular electronics and paves the way for designing next-generation molecular devices with tailored functions like rectification and conductance switching.
Professor Hiraku Matsukuma's research lab specializes in advanced photonics and laser technologies, with a focus on rare-earth-doped fluoride fiber lasers operating in the mid-infrared region, particularly around 2.8–3.5 μm. The lab develops high-power, Q-switched fiber laser systems using novel pump schemes and components such as acousto-optic modulators and side-pump couplers. It also explores ultrafast laser applications in precision metrology, including optical angle measurement and confocal surface profiling using femtosecond and supercontinuum light sources. Additionally, the lab investigates laser-plasma interactions, especially for extreme ultraviolet (EUV) light generation in laser-produced tin plasmas, aiming to optimize conversion efficiency and understand absorption dynamics.
Professor Tetsuo Endoh's research lab specializes in advanced semiconductor devices and non-volatile memory technologies, with a strong focus on spintronic-based memory systems such as STT-MRAM and SOT-MRAM. The lab pioneers innovative device structures—like stacked-surrounding gate transistors (S-SGT) and gate-all-around (GAA) MOSFETs—to overcome scaling limitations in nanoscale memory and logic devices. Key research directions include high-density, low-power, and high-reliability memory solutions using advanced materials (e.g., CoFeB/MgO) and novel fabrication processes (e.g., 300mm integration, PVD, RIE). The lab also investigates fundamental phenomena such as band-to-band tunneling and interface engineering to enhance device performance and reliability.
