东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Takeshi Yoshida's research lab specializes in respiratory physiology and critical care medicine, focusing on the biomechanics of mechanical ventilation and its impact on lung injury. The lab investigates how spontaneous breathing efforts during mechanical ventilation can inadvertently cause or exacerbate ventilator-induced lung injury (VILI), particularly through excessive transpulmonary pressure and tidal recruitment. Using animal models and clinical monitoring techniques like esophageal manometry, the lab aims to optimize ventilatory strategies to balance oxygenation benefits with lung-protective ventilation. Their work emphasizes personalized PEEP titration and the hemodynamic and ventilatory consequences of spontaneous effort in acute respiratory distress syndrome (ARDS).
Professor Takayoshi Sakai's research lab specializes in developmental biology and regenerative medicine, with a focus on salivary gland morphogenesis, stem cell biology, and the molecular mechanisms underlying organ development and regeneration. The lab investigates signaling pathways in neural and epithelial development, including the role of semaphorins and growth factors in neurite outgrowth and branching morphogenesis. It also explores the potential of induced pluripotent stem (iPS) cells for salivary gland regeneration and examines the role of host microenvironments (niche) in tissue repair. Additionally, the lab contributes to understanding viral pathogenesis, particularly SARS-CoV-2 entry mechanisms via ACE2 expression in salivary glands. These interdisciplinary efforts integrate developmental biology, stem cell technology, and translational medicine to advance regenerative therapies and disease modeling.
Professor Takeshi Noda's research lab focuses on the molecular mechanisms underlying autophagy, particularly the regulation of autophagosome formation and the signaling pathways that control this essential cellular degradation process. The lab investigates key regulators such as the TOR kinase and the VPS34-PI3K complex, with a special emphasis on the role of Atg14L in organizing autophagic membranes at the endoplasmic reticulum. By studying both yeast and mammalian systems, the lab aims to elucidate how cells switch between selective and bulk degradation pathways in response to environmental cues like nutrient availability.
Professor Kento Katagiri's research lab specializes in high-pressure and dynamic materials science, focusing on the extreme-state behavior of advanced materials under shock compression and ultrahigh strain rates. The lab combines in situ femtosecond x-ray techniques, ab initio molecular dynamics, and diamond anvil cell experiments to investigate phase transitions, defect dynamics, and structural responses in materials such as diamond, tantalum, polyimide, and high-entropy alloys. A central theme is understanding the fundamental limits of material performance—such as dislocation velocities, tensile strength in liquids, and elastic limits—under conditions relevant to planetary interiors, inertial confinement fusion, and next-generation structural materials.
Professor Yusuke Mukuhira's research lab specializes in geomechanics and induced seismicity, focusing on the physical mechanisms of fluid-induced earthquakes during hydraulic stimulation and reservoir engineering. The lab investigates pore pressure migration, fault reactivation, and stress-state controls on seismicity using in-situ stress data, microseismic monitoring, and Coulomb failure criteria. Their work bridges fundamental rock mechanics with practical applications in geothermal energy development and seismic hazard mitigation.
Professor Shin-ichi Izumi's research lab specializes in diagnostic imaging and interventional radiology, with a primary focus on advancing ultrasound-guided procedures for accurate and safe tissue diagnosis in thoracic diseases. The lab emphasizes the development and clinical application of innovative imaging techniques, such as ultrasonically guided aspiration needle biopsy, to improve early detection of lung and chest wall pathologies. Their work centers on enhancing diagnostic accuracy while minimizing patient risk through precise, real-time imaging guidance. The lab also contributes to the refinement of minimally invasive diagnostic methods in pulmonology and chest radiology.
Professor Yutaka S. Sato's research lab specializes in advanced joining technologies for lightweight structural materials, with a primary focus on friction stir welding and related solid-state joining processes. The lab investigates the microstructural evolution, interfacial reactions, and mechanical properties of dissimilar metal joints, particularly in aluminum and magnesium alloys used in the automotive and aerospace industries. Current research directions emphasize process optimization, defect control, and the development of high-strength, reliable joints for next-generation lightweight structures. The lab also explores the role of intermetallic compound formation and its impact on joint performance under various welding conditions.
Professor Yasuyuki Yamada's research lab specializes in the design and synthesis of functional molecular and supramolecular architectures with applications in advanced materials and catalysis. The lab focuses on creating complex, multi-component systems through precise molecular recognition and coordination strategies, particularly using porphyrin and phthalocyanine units. Key research directions include the development of stimuli-responsive materials, such as redox- and fluorescence-switchable sensors, and the construction of well-defined, stacked metal complexes for applications in molecular electronics and catalysis. The lab also investigates superconducting oxide materials and ferroelectric perovskites, emphasizing structure-property relationships in complex oxide systems.
Professor Hiroaki Oda's research lab focuses on the intersection of circadian rhythms, lipid metabolism, and metabolic health, particularly in the context of eating behavior and dietary patterns. The lab investigates how meal timing—especially breakfast skipping and delayed feeding—affects the hepatic circadian clock and subsequent dysregulation of lipid metabolism, contributing to conditions like fatty liver and obesity. A central theme is chrononutrition, exploring how regular eating habits can entrain biological clocks and improve metabolic parameters such as cholesterol and triglyceride levels. The lab also examines the role of metabolic and hormonal pathways, including insulin and renin-angiotensin system components, in metabolic and cardiovascular diseases.
Professor Hiroyuki Nakaoka's research lab specializes in advanced homological algebra and category theory, focusing on extriangulated categories as a unifying framework that generalizes both exact and triangulated categories. The lab investigates cotorsion pairs, Hovey twin cotorsion pairs, and their connections to model structures, homotopy categories, and recollements in triangulated settings. A central theme is the development of generalized reduction and mutation operations for cotorsion pairs, particularly through the concept of concentric twin cotorsion pairs, which unify t-structures, cluster tilting, and co-t-structures. The lab also explores applications in algebraic topology and representation theory, including Tambara functors and their role in Witt–Burnside constructions.
Professor Yosuke Taniguchi's research lab specializes in the design and synthesis of novel nucleoside analogues for advanced DNA recognition and detection. The lab focuses on developing non-natural nucleosides that enable selective recognition of damaged DNA bases—particularly 8-oxo-2'-deoxyguanosine—without enzymatic or chemical pretreatment, leveraging unique fluorescent and stabilizing properties. Another key direction involves creating innovative scaffolds, such as W-shaped nucleoside analogues (WNA), to overcome limitations in triplex-forming oligonucleotides, especially at sequence-incompatible sites like TA or CG interruptions. The lab also explores shape-mimic nucleosides that replicate the mutagenic behavior of oxidatively damaged purines, providing tools for studying DNA damage and repair mechanisms.
Professor Toshiharu Ninomiya's research lab focuses on the intersection of metabolic and cardiovascular diseases, with a strong emphasis on diabetes, kidney function, and cerebrovascular health. The lab investigates the long-term impact of biomarkers such as albuminuria and estimated glomerular filtration rate (eGFR) on cardiovascular and renal outcomes in diabetic populations. It also explores the complex relationships between hypertension, dementia, and lifestyle factors such as diet, particularly in aging Japanese cohorts. The research aims to identify modifiable risk factors and improve preventive strategies for chronic diseases in aging populations.
Professor Katsuro Hayashi's research lab specializes in advanced oxide materials for energy conversion and storage, with a focus on ion-conducting ceramics, defect chemistry in complex oxides, and reactive oxygen species in nanostructured frameworks. The lab investigates the fundamental behavior of charged species—such as O⁻, O₂⁻, OH⁻, and H⁻—in materials like C12A7 (mayenite) and NASICON, combining experimental techniques with ab initio calculations to understand their electronic structure and reactivity. Key research directions include solid-state ionics, oxygen radical generation under high pO₂, and the development of robust solid electrolytes for all-solid-state batteries, particularly with sodium metal anodes. The lab also explores aqueous Na–air cells and interfacial phenomena in battery systems to enable high-energy-density, cost-effective energy storage solutions.
Professor Takahiko Miyazaki's research lab specializes in adsorption science and materials engineering, focusing on the development and application of advanced adsorbents for environmental and energy-related technologies. The lab investigates porous materials such as silica gel and carbon-based adsorbents (CBAs) for efficient water vapor capture, with particular emphasis on dehumidification in greenhouses and low-temperature regeneration processes. Key research directions include adsorption isotherms, thermodynamic modeling (e.g., GAB and Dubinin-Astakhov models), and optimizing adsorbent performance for sustainable climate control systems. The lab aims to enhance energy efficiency and reduce material usage in humidity control through innovative adsorbent design and characterization.
Professor Yongpeng Tang's research lab specializes in advanced processing and microstructure engineering of lightweight aluminum alloys, with a focus on severe plastic deformation techniques such as high-pressure torsion (HPT), high-pressure sliding (HPS), and accumulative roll bonding (ARB). The lab investigates grain refinement, dislocation dynamics, and precipitation hardening to enhance mechanical properties like tensile strength, ductility, and superplasticity. Key research directions include the development of ultrafine-grained and nanocrystalline aluminum alloys with tailored microstructures for high-performance structural applications.
Professor Koutarou Matsumoto's research lab specializes in developing and validating data-driven predictive models for neurological emergencies, with a focus on acute ischemic stroke and intracerebral hemorrhage. The lab integrates real-world clinical data, medical imaging, and machine learning to enhance clinical decision support systems, particularly for non-specialists in emergency settings. Key research directions include multimodal risk prediction, model calibration, and leveraging learning health systems to optimize patient outcomes.
Professor Hiroaki Niiro's research lab focuses on innate immune regulation, particularly the role of anti-inflammatory cytokines such as IL-10 and IL-4 in modulating prostanoid production and cyclooxygenase (COX) expression in human myeloid cells like neutrophils and monocytes. The lab investigates molecular mechanisms underlying the suppression of inflammatory mediators, with a central emphasis on COX-2 gene regulation and downstream signaling pathways. Their work also extends to B cell signaling, exploring the function of adaptor proteins like Bam32 in B cell receptor signaling and calcium mobilization. Overall, the lab aims to uncover therapeutic targets for inflammatory and immune-mediated diseases through detailed immunological and molecular analyses.
Professor Yuji Masubuchi's research lab specializes in the development and characterization of novel oxynitride perovskite materials, focusing on their synthesis, structural stability, and functional properties. The lab explores innovative sintering and flux-based methods to achieve high-density ceramics and thin films with tailored dielectric and luminescent responses. A key research direction involves designing materials for high-pressure sensing and energy-efficient dielectrics, leveraging unique electronic and structural features such as polar nanoregions and large piezoelectric responses. The lab also investigates low-temperature nitridation routes using carbon nitrides to enable stoichiometric control and enhanced material performance.
Professor Kosuke Takahashi's research lab specializes in advanced functional materials and structural health monitoring, with a focus on graphite/polymer composites, radical chemistry for borane-based synthesis, and the development of smart materials for renewable energy systems. The lab investigates the electrical and mechanical behavior of composite materials under thermal and mechanical stress, while pioneering innovative non-destructive evaluation techniques such as the addressable conducting network for real-time damage detection. Additionally, the group develops novel synthetic methodologies using N-heterocyclic carbene boranes for creating thermally stable, functional materials, including liquid crystals and high-performance polymers. Their work bridges materials chemistry, mechanical engineering, and structural integrity assessment, particularly in wind energy applications and carbon fiber composites.
Professor Yusuke Takahashi's research lab specializes in the numerical simulation and analysis of plasma flows and electromagnetic wave propagation during atmospheric reentry. The lab focuses on predicting and mitigating radio frequency blackout caused by ionized shock layers, integrating computational fluid dynamics with advanced electromagnetic modeling. Key research directions include thermochemical nonequilibrium flow simulations, plasma-electromagnetic wave coupling, and the development of high-fidelity numerical methods for reentry vehicles and arc-heated facilities. The lab also explores innovative mitigation strategies, such as surface catalysis, to enhance communication reliability during hypersonic flight.
